{"id":"W1972032312","doi":"10.1515/bc.2007.037","title":"Effects of disease-modifying anti-rheumatic drugs (DMARDs) on the activities of rheumatoid arthritis-associated cathepsins K and S","year":2007,"lang":"en","type":"article","venue":"Biological Chemistry","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","keywords":"Rheumatoid arthritis; Cathepsin; Chloroquine; Auranofin; Cathepsin S; Medicine; Pharmacology; Arthritis; Cathepsin B; Gold Compounds; Inflammation; Cathepsin K; Immunology; Chemistry; Internal medicine; Receptor; Enzyme; Biochemistry; Combinatorial chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005059869,0.0001653326,0.0004472672,0.00002981601,0.00009674447,0.00001176476,0.0001124458,0.0001239866,0.0000634641],"category_scores_gemma":[0.001324998,0.00009931661,0.0001212149,0.0001128428,0.000604743,0.00002775638,0.00006474952,0.0002302432,0.000001892367],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002850434,"about_ca_system_score_gemma":0.00005235951,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001938409,"about_ca_topic_score_gemma":9.267633e-7,"domain_scores_codex":[0.9988049,0.00006784911,0.0003147577,0.0002042173,0.0002925884,0.0003156844],"domain_scores_gemma":[0.9979942,0.00141338,0.0001510458,0.0002048165,0.00005970424,0.0001768514],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008682313,0.0008605882,0.03175662,0.000688418,0.000239826,0.00004364715,0.0006205507,3.51324e-7,0.9484609,0.000467534,0.0001162673,0.01587705],"study_design_scores_gemma":[0.002203491,0.0003533551,0.1378085,0.002618504,0.000004378206,0.00001715979,0.0008649998,0.00002111923,0.8552248,0.0005191409,0.0001915312,0.0001729624],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897422,0.009014797,0.00001292362,0.0001732684,0.00002101132,0.000270237,0.00002388908,0.00003893543,0.0007028031],"genre_scores_gemma":[0.9623219,0.03752438,0.00002211703,0.00004806964,0.0000148354,0.0000158567,0.0000166863,0.00001095871,0.00002518536],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1060519,"threshold_uncertainty_score":0.4050014,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0145390863174419,"score_gpt":0.2577620041932216,"score_spread":0.2432229178757797,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}