{"id":"W1972044356","doi":"10.1007/s00213-005-2223-5","title":"Association study of 12 polymorphisms spanning the dopamine D2 receptor gene and clozapine treatment response in two treatment refractory/intolerant populations","year":2005,"lang":"en","type":"article","venue":"Psychopharmacology","topic":"Schizophrenia research and treatment","field":"Medicine","cited_by":97,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"","keywords":"Clozapine; Single-nucleotide polymorphism; Linkage disequilibrium; Haplotype; Antipsychotic; Population; Dopamine receptor D2; Genetics; Biology; Allele; Internal medicine; Schizophrenia (object-oriented programming); Genotype; Medicine; Receptor; Gene; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004596837,0.0002464461,0.0004716591,0.0003076851,0.0001286365,0.00001181459,0.00007108944,0.00006507662,0.0003765778],"category_scores_gemma":[0.00006784735,0.0001586027,0.00008344125,0.0002581978,0.00005180451,0.00006194328,0.00002505931,0.0001556846,0.00003065248],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001502667,"about_ca_system_score_gemma":0.0001351563,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001161678,"about_ca_topic_score_gemma":0.002831374,"domain_scores_codex":[0.9978993,0.0005717505,0.0004851456,0.0003815833,0.0002831444,0.0003790812],"domain_scores_gemma":[0.9988924,0.0003553215,0.0002034793,0.000298178,0.00007269937,0.0001779827],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1515219,0.01831124,0.6218315,0.000009094201,0.001747414,0.0002000278,0.005642004,0.0002449685,0.1095338,0.00002792675,0.0006663622,0.09026372],"study_design_scores_gemma":[0.07472751,0.01309287,0.9000967,0.00001955772,0.0005974171,0.00004124161,0.0004417956,0.0005616383,0.005822896,0.00001794221,0.004415081,0.0001653436],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856935,0.001938372,0.000004830204,0.01024952,0.0002471529,0.00175316,0.00002781866,0.00003148012,0.00005413798],"genre_scores_gemma":[0.9959183,0.000897358,0.0009426071,0.000146813,0.0003281553,0.0004758576,0.00003712221,0.00002479677,0.001228986],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2782651,"threshold_uncertainty_score":0.646763,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05097121278716402,"score_gpt":0.4003351247564634,"score_spread":0.3493639119692994,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}