{"id":"W1972045169","doi":"10.1111/j.1600-079x.2009.00724.x","title":"Inhibition of procarcinogen‐bioactivating human CYP1A1, CYP1A2 and CYP1B1 enzymes by melatonin","year":2009,"lang":"en","type":"article","venue":"Journal of Pineal Research","topic":"Circadian rhythm and melatonin","field":"Neuroscience","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"CYP1A2; CYP1B1; Melatonin; Microsome; CYP2A6; Cytochrome P450; Chemistry; Carcinogen; Hydroxylation; Biochemistry; Aryl hydrocarbon receptor; Enzyme; Biology; Endocrinology; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001806608,0.0004304391,0.0002542638,0.0001897158,0.0001342811,0.0002091727,0.0001132649,0.0001561903,0.00119145],"category_scores_gemma":[0.0001639628,0.0001473647,0.0002994801,0.0001591233,0.0001825498,0.0001355182,0.0000880228,0.0003267664,0.0002478311],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001973611,"about_ca_system_score_gemma":0.0001722057,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007134114,"about_ca_topic_score_gemma":0.001299453,"domain_scores_codex":[0.9998749,0.0000345016,0.00001191955,0.00002592517,0.0000260463,0.0000265968],"domain_scores_gemma":[0.9998642,0.00002084423,0.0000587523,0.00001446236,0.00001497604,0.00002662171],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004334686,0.00006534968,0.0004919748,0.00004135581,0.00001487606,0.00001905313,0.00001408406,0.00003951445,0.9964961,0.00003759031,0.00003648963,0.002310214],"study_design_scores_gemma":[0.00008572544,0.002482465,0.01179509,0.000004529533,0.00004584401,0.0001101551,0.00001494906,0.0004410384,0.9831003,0.00002445513,0.001890852,0.000004749717],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933049,0.004047679,0.00143962,0.00006664447,0.00002746582,0.00003454425,0.0001848249,0.00008985741,0.0008043279],"genre_scores_gemma":[0.9936097,0.002154999,0.001810104,0.00003183985,0.00002789767,0.00004721168,0.0003989588,0.00001787572,0.00190138],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00119145,"threshold_uncertainty_score":0.003985763,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08536343263248664,"score_gpt":0.382012797067667,"score_spread":0.2966493644351804,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}