{"id":"W1972105230","doi":"10.1186/bcr2252","title":"QLT0267, a small molecule inhibitor targeting integrin-linked kinase (ILK), and docetaxel can combine to produce synergistic interactions linked to enhanced cytotoxicity, reductions in P-AKT levels, altered F-actin architecture and improved treatment outcomes in an orthotopic breast cancer model","year":2009,"lang":"en","type":"article","venue":"Breast Cancer Research","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; QLT (Canada); BC Cancer Agency","funders":"BC Cancer Agency; Canadian Breast Cancer Research Alliance; McGill University; Georgetown University","keywords":"Docetaxel; Cytotoxicity; Surgical oncology; Chemistry; Protein kinase B; Cancer research; Integrin-linked kinase; Small molecule; Cell biology; Kinase; Biochemistry; Phosphorylation; Biology; Protein kinase A; Medicine; Cancer; Internal medicine; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000150035,0.0004125344,0.0003205906,0.0003015964,0.0001142993,0.0003373766,0.0001891587,0.0001955315,0.001047096],"category_scores_gemma":[0.00007677952,0.0001556504,0.0002497039,0.0002326141,0.0001954466,0.0001565504,0.0001561126,0.0004150647,0.0003340651],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003874783,"about_ca_system_score_gemma":0.0003735411,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007970455,"about_ca_topic_score_gemma":0.002317348,"domain_scores_codex":[0.9998375,0.0000216585,0.00001484618,0.00002456683,0.00005937726,0.00004200143],"domain_scores_gemma":[0.9999216,0.00001424254,0.00002433361,0.00000643667,0.000007352963,0.00002601048],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004243901,0.0002618783,0.0004073347,0.00008511776,0.00002443253,0.00006804967,0.00001318755,0.0002569903,0.9941534,0.00008129836,0.0001394598,0.004084501],"study_design_scores_gemma":[0.0001126211,0.003328699,0.002698796,0.000005921308,0.00004941583,0.0003650925,0.00001411779,0.0007547745,0.9910867,0.00001193193,0.001566271,0.000005755796],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929965,0.001852766,0.001766164,0.00008614049,0.00003022351,0.00008226562,0.0002319551,0.00008994472,0.002864118],"genre_scores_gemma":[0.9948315,0.0009717012,0.001927751,0.00004906667,0.00001044967,0.0000433485,0.0004094891,0.00001494648,0.001741752],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001047096,"threshold_uncertainty_score":0.003502905,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06660494242434903,"score_gpt":0.3939242008427045,"score_spread":0.3273192584183554,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}