{"id":"W1972105230","doi":"10.1186/bcr2252","title":"QLT0267, a small molecule inhibitor targeting integrin-linked kinase (ILK), and docetaxel can combine to produce synergistic interactions linked to enhanced cytotoxicity, reductions in P-AKT levels, altered F-actin architecture and improved treatment outcomes in an orthotopic breast cancer model","year":2009,"lang":"en","type":"article","venue":"Breast Cancer Research","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; QLT (Canada); BC Cancer Agency","funders":"BC Cancer Agency; Canadian Breast Cancer Research Alliance; McGill University; Georgetown University","keywords":"Docetaxel; Cytotoxicity; Surgical oncology; Chemistry; Protein kinase B; Cancer research; Integrin-linked kinase; Small molecule; Cell biology; Kinase; Biochemistry; Phosphorylation; Biology; Protein kinase A; Medicine; Cancer; Internal medicine; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006484562,0.0005315664,0.0008636738,0.001315,0.0002675718,0.000179691,0.0003025593,0.0001770585,0.000106689],"category_scores_gemma":[0.0004036628,0.0004592002,0.00009297942,0.00158419,0.0001850639,0.000151617,0.0003346844,0.001521944,0.000004828149],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002020027,"about_ca_system_score_gemma":0.001100335,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.02422045,"about_ca_topic_score_gemma":0.05536554,"domain_scores_codex":[0.9953136,0.0004335688,0.00074948,0.001485317,0.0007216953,0.001296306],"domain_scores_gemma":[0.9971874,0.0001655958,0.0001003462,0.0007408365,0.0006815302,0.001124265],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002722679,0.001423182,0.005675454,0.0001404778,0.00006224521,0.0001062321,0.002641684,0.00164592,0.9472094,0.00001798183,0.00005037582,0.03830442],"study_design_scores_gemma":[0.01075262,0.002778952,0.7657517,0.001875617,0.00009458701,0.000301804,0.001756817,0.01964117,0.1955681,0.0002132575,0.00008132268,0.00118408],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9650957,0.0001511679,0.000328598,0.02997214,0.0001058498,0.003788303,0.0004462985,0.00006800157,0.00004394836],"genre_scores_gemma":[0.9947233,0.0001179236,0.001256373,0.0004170441,0.0003043169,0.001913832,0.00005108945,0.00008459324,0.001131566],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7600762,"threshold_uncertainty_score":0.999786,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06660494242434903,"score_gpt":0.3939242008427045,"score_spread":0.3273192584183554,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}