{"id":"W1972108154","doi":"10.1016/s0006-2952(01)00798-5","title":"Reduction in serotonin synthesis following acute and chronic treatments with paroxetine, a selective serotonin reuptake inhibitor, in rat brain: an autoradiographic study with α-[ 14 C]methyl- l -tryptophan 2 2Abbreviations: 5-HT, serotonin, 5-hydroxytryptamine; α-[14C]MTrp, α-[14C]methyl-l-tryptophan; SSRI, selective serotonin reuptake inhibitor; and α-[14C]M5HT, α-[14C]methyl-5-HT.","year":2001,"lang":"en","type":"article","venue":"Biochemical Pharmacology","topic":"Neurotransmitter Receptor Influence on Behavior","field":"Neuroscience","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University","funders":"National Institute of Neurological Disorders and Stroke","keywords":"Serotonin; Serotonergic; Dorsal raphe nucleus; Medial forebrain bundle; Paroxetine; Endocrinology; Internal medicine; Chemistry; Tryptophan hydroxylase; Substantia nigra; Ventral tegmental area; 5-HT receptor; Raphe nuclei; Biology; Striatum; Dopamine; Dopaminergic; Medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001850374,0.0007067921,0.0008603816,0.0007982746,0.0004271184,0.0004487585,0.0005541404,0.0006877787,0.004762842],"category_scores_gemma":[0.0001946315,0.0006132442,0.0008093451,0.0004818208,0.0007752414,0.0005714039,0.0002576104,0.001542872,0.001028347],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008211558,"about_ca_system_score_gemma":0.0005147446,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007858506,"about_ca_topic_score_gemma":0.01725822,"domain_scores_codex":[0.9998516,0.00001379568,0.000007608612,0.00003495378,0.00002186063,0.00007018047],"domain_scores_gemma":[0.9997538,0.00004761529,0.00005013623,0.000036786,0.00003583676,0.00007581558],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005787551,0.0003165147,0.0008660943,0.0001735971,0.0001035236,0.0003031166,0.0001581996,0.00004265363,0.9868115,0.0001316955,0.0002093234,0.005096317],"study_design_scores_gemma":[0.0002338017,0.006039937,0.05637156,0.00002778314,0.0003214255,0.0008097145,0.0002611621,0.0004250873,0.932411,0.0001405915,0.002919374,0.00003860056],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872046,0.005680679,0.001189937,0.000193089,0.000123418,0.00005377815,0.002160521,0.000133623,0.003260272],"genre_scores_gemma":[0.9697352,0.004668278,0.001690794,0.0001274805,0.00007001466,0.0001857442,0.003703447,0.00006848799,0.01975057],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007858506,"threshold_uncertainty_score":0.01593328,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01695371471921022,"score_gpt":0.2995539494407531,"score_spread":0.2826002347215429,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}