{"id":"W1972108154","doi":"10.1016/s0006-2952(01)00798-5","title":"Reduction in serotonin synthesis following acute and chronic treatments with paroxetine, a selective serotonin reuptake inhibitor, in rat brain: an autoradiographic study with α-[ 14 C]methyl- l -tryptophan 2 2Abbreviations: 5-HT, serotonin, 5-hydroxytryptamine; α-[14C]MTrp, α-[14C]methyl-l-tryptophan; SSRI, selective serotonin reuptake inhibitor; and α-[14C]M5HT, α-[14C]methyl-5-HT.","year":2001,"lang":"en","type":"article","venue":"Biochemical Pharmacology","topic":"Neurotransmitter Receptor Influence on Behavior","field":"Neuroscience","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University","funders":"National Institute of Neurological Disorders and Stroke","keywords":"Serotonin; Serotonergic; Dorsal raphe nucleus; Medial forebrain bundle; Paroxetine; Endocrinology; Internal medicine; Chemistry; Tryptophan hydroxylase; Substantia nigra; Ventral tegmental area; 5-HT receptor; Raphe nuclei; Biology; Striatum; Dopamine; Dopaminergic; Medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.001699888,0.002650633,0.002913117,0.002567667,0.0009352765,0.0004565365,0.001358267,0.001241371,0.0001438329],"category_scores_gemma":[0.0005459915,0.002503258,0.000415881,0.007739146,0.001532104,0.002348529,0.0004636461,0.003256448,0.00003058627],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001991143,"about_ca_system_score_gemma":0.0009856788,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005616037,"about_ca_topic_score_gemma":0.0003254962,"domain_scores_codex":[0.9830635,0.003960814,0.002476716,0.005598683,0.001731844,0.003168489],"domain_scores_gemma":[0.9942938,0.001337584,0.001202802,0.001408086,0.0004382907,0.001319413],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004479515,0.003991892,0.09295616,0.000179024,0.0005057096,0.001637164,0.002516359,0.0001625078,0.8913742,0.00001360393,0.000581606,0.001602256],"study_design_scores_gemma":[0.01720446,0.007634213,0.03811757,0.0005860038,0.001156482,0.001313446,0.0008248659,0.0005512089,0.9294482,0.00006812164,0.0005913142,0.002504086],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9800845,0.001330891,0.00003362724,0.001264287,0.0008153666,0.01557979,0.0001272402,0.0006757309,0.00008860895],"genre_scores_gemma":[0.9830995,0.001082981,0.001575112,0.0008309545,0.0005207704,0.01210888,0.00006429169,0.0004672107,0.0002502759],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05483859,"threshold_uncertainty_score":0.9990431,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01695371471921022,"score_gpt":0.2995539494407531,"score_spread":0.2826002347215429,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}