{"id":"W1972126235","doi":"10.1371/journal.pone.0030802","title":"Coronavirus Papain-like Proteases Negatively Regulate Antiviral Innate Immune Response through Disruption of STING-Mediated Signaling","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":275,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; National Natural Science Foundation of China; U.S. Department of Defense","keywords":"Sting; Innate immune system; Stimulator of interferon genes; IRF3; Cell biology; Biology; Interferon; TANK-binding kinase 1; RIG-I; Inflammasome; Endoplasmic reticulum; Proteases; Signal transduction; Virology; Immune system; Immunology; Inflammation; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001265511,0.0003275062,0.0001935576,0.0001268065,0.0001201471,0.0003142249,0.000112023,0.0002085267,0.0008735733],"category_scores_gemma":[0.00008543875,0.0001073684,0.000240988,0.00008523979,0.0002261504,0.0002081838,0.0001681381,0.0004245334,0.0002696472],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002679121,"about_ca_system_score_gemma":0.0001129361,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001652894,"about_ca_topic_score_gemma":0.0002243635,"domain_scores_codex":[0.9998592,0.00003507025,0.00001586353,0.00002517987,0.00003072362,0.00003396941],"domain_scores_gemma":[0.9999117,0.00001157517,0.00003193721,0.00001271303,0.000009662694,0.00002243672],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005731813,0.000008617835,0.0001509783,0.00002066651,0.000003552116,0.0000293711,0.000004929518,0.00002219404,0.9991686,0.00004785133,0.00001539031,0.000470602],"study_design_scores_gemma":[0.00001799412,0.0001465936,0.01093495,0.000006822169,0.0000149523,0.0004131617,0.00002589392,0.001226019,0.9851251,0.00007919567,0.002005897,0.000003553828],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935867,0.003167809,0.001724867,0.00009542425,0.00002235264,0.00001590961,0.0002063142,0.00006586123,0.001114776],"genre_scores_gemma":[0.9976225,0.0006084053,0.0007398631,0.00003086378,0.000007530078,0.00001123536,0.0002043579,0.000005716755,0.0007694309],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008735733,"threshold_uncertainty_score":0.002922356,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07945372223375477,"score_gpt":0.2874151050030943,"score_spread":0.2079613827693395,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}