{"id":"W1972132259","doi":"10.1517/17460441.2013.798296","title":"Advances in the development of hybrid anticancer drugs","year":2013,"lang":"en","type":"review","venue":"Expert Opinion on Drug Discovery","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":226,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Trois-Rivières","funders":"","keywords":"Anticancer drug; Drug discovery; Histone deacetylase; Computational biology; Pharmacology; Medicine; Drug; Bioinformatics; Biology; Histone; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000425152,0.0003629994,0.0006840955,0.0001496776,0.00007163583,0.00004348906,0.0006754408,0.0001143029,0.00002986321],"category_scores_gemma":[0.00007872016,0.0002325557,0.000282374,0.0001758295,0.0001484119,0.00001876115,0.0001846911,0.0002778895,0.00006794652],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009670443,"about_ca_system_score_gemma":0.0006639365,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001421496,"about_ca_topic_score_gemma":0.000009608936,"domain_scores_codex":[0.9976205,0.0003166002,0.0006671706,0.0005446566,0.0005218876,0.0003292289],"domain_scores_gemma":[0.9988876,0.00009982246,0.0002437411,0.00067486,0.00004391034,0.00005006471],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002327095,0.0002093107,8.090932e-7,0.001488304,0.00003785502,0.000002300982,0.0005098737,0.000003658543,0.0001598047,0.00005409939,0.02074666,0.976764],"study_design_scores_gemma":[0.0001553366,0.00004646508,4.886261e-7,0.00314502,0.000002468366,0.000005143852,0.0002074879,8.555305e-7,0.00746035,0.000003383291,0.9886991,0.0002738493],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005517031,0.9958354,0.00004034103,0.00004574229,0.0005099109,0.0007605383,0.00003523217,0.000004712396,0.002216413],"genre_scores_gemma":[0.0005620038,0.9971077,0.0001311157,0.00007232952,0.0004338947,0.000567749,0.0004950237,0.0000478705,0.0005822859],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9764902,"threshold_uncertainty_score":0.9483347,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03213998738206073,"score_gpt":0.3785754578168257,"score_spread":0.346435470434765,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}