{"id":"W1972139510","doi":"10.1093/emboj/19.7.1613","title":"SCFMet30‐mediated control of the transcriptional activator Met4 is required for the G1–S transition","year":2000,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":97,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"National Cancer Institute; Medical Research Council; Centre National de la Recherche Scientifique","keywords":"Biology; Ubiquitin ligase; Cell biology; Transcription (linguistics); Mutant; Genetics; Transcription factor; Activator (genetics); Cell cycle; Schizosaccharomyces pombe; Gene; Promoter; Saccharomyces cerevisiae; Molecular biology; Ubiquitin; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004479747,0.00009907476,0.000107622,0.00001055673,0.0003175029,0.00002915936,0.0003597615,0.0000650377,0.0001713124],"category_scores_gemma":[0.00002494911,0.00004791859,0.0002579663,0.00005416497,0.0001155689,0.000004375744,0.000007610737,0.0001339301,0.000002185005],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001367124,"about_ca_system_score_gemma":0.00009339739,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003651946,"about_ca_topic_score_gemma":0.000005203959,"domain_scores_codex":[0.9992576,0.00009007219,0.0002331853,0.00009687567,0.0001493856,0.0001729283],"domain_scores_gemma":[0.9994864,0.000052016,0.0001188661,0.0002269192,0.00007859337,0.00003723817],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000476339,0.00005862198,0.0000420792,0.000008934117,0.0003285269,3.191666e-7,0.000530143,0.001765279,0.9910546,0.0001494112,0.00161526,0.003970471],"study_design_scores_gemma":[0.01953764,0.001738258,0.03202958,0.0001527701,0.001747867,0.00122914,0.002222779,0.07261722,0.527794,0.0158363,0.3240077,0.001086675],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9823379,0.0007673656,0.0100755,0.006023435,0.00019701,0.0002816021,0.000177079,0.000002434477,0.0001376929],"genre_scores_gemma":[0.997368,0.0003229651,0.0001208868,0.001459998,0.000362064,0.00001305088,0.00001456202,0.00001464931,0.0003238225],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4632606,"threshold_uncertainty_score":0.2442008,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008041837350076648,"score_gpt":0.217064716222974,"score_spread":0.2090228788728974,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}