{"id":"W1972147779","doi":"10.1016/j.cbi.2004.10.005","title":"Peroxidase catalysed formation of cytotoxic prooxidant phenothiazine free radicals at physiological pH","year":2004,"lang":"en","type":"article","venue":"Chemico-Biological Interactions","topic":"Phenothiazines and Benzothiazines Synthesis and Activities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Ontario Neurotrauma Foundation","keywords":"Chemistry; Phenothiazine; Butylated hydroxyanisole; Radical; Peroxidase; Superoxide dismutase; Antioxidant; Cytotoxicity; Biochemistry; Enzyme; Pharmacology; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001273603,0.0003080793,0.0004062437,0.00005512315,0.0001867493,0.00002311529,0.0003939912,0.0002578803,0.0003172615],"category_scores_gemma":[0.000444498,0.0002168234,0.0003290731,0.0001200149,0.0003271087,0.0000286911,0.0003365236,0.0002098568,0.00004161655],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009000349,"about_ca_system_score_gemma":0.00004064653,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002204392,"about_ca_topic_score_gemma":0.0000193496,"domain_scores_codex":[0.9984287,0.00005467685,0.0005256454,0.0004763142,0.0001512522,0.0003633935],"domain_scores_gemma":[0.9988798,0.00006006499,0.0002806822,0.000524872,0.0001209,0.0001336735],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001996806,0.0005287592,0.00007543196,0.00003298239,0.00005085216,0.000002790502,0.00007109156,0.00005193341,0.9964235,0.0002861777,0.001909916,0.0003669296],"study_design_scores_gemma":[0.0008689685,0.0003430269,0.001015055,0.00005274958,0.00002809375,0.00006241661,0.0001524182,0.00002601983,0.9874074,0.0009951055,0.008754188,0.000294565],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955935,0.0003856062,0.001058942,0.0004918917,0.0001618313,0.0002641307,0.0001451924,0.00004947826,0.001849356],"genre_scores_gemma":[0.9973218,0.0002170242,0.0007198041,0.0003401123,0.0004203504,0.00009762283,0.0004981387,0.00001987213,0.0003653122],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009016063,"threshold_uncertainty_score":0.8841802,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03336841357396643,"score_gpt":0.2715345796879525,"score_spread":0.2381661661139861,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}