{"id":"W1972147779","doi":"10.1016/j.cbi.2004.10.005","title":"Peroxidase catalysed formation of cytotoxic prooxidant phenothiazine free radicals at physiological pH","year":2004,"lang":"en","type":"article","venue":"Chemico-Biological Interactions","topic":"Phenothiazines and Benzothiazines Synthesis and Activities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Ontario Neurotrauma Foundation","keywords":"Chemistry; Phenothiazine; Butylated hydroxyanisole; Radical; Peroxidase; Superoxide dismutase; Antioxidant; Cytotoxicity; Biochemistry; Enzyme; Pharmacology; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002983143,0.0004724246,0.0002606135,0.0001383542,0.0001379328,0.0002049117,0.0002626382,0.0003443319,0.001145898],"category_scores_gemma":[0.0002553909,0.0001889574,0.0002075029,0.000156706,0.0002916869,0.0003135881,0.0002106335,0.0004813303,0.0002190618],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002777191,"about_ca_system_score_gemma":0.0001696966,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004698939,"about_ca_topic_score_gemma":0.0003678686,"domain_scores_codex":[0.9998736,0.00002862959,0.000006433809,0.00002335697,0.00002821629,0.00003966097],"domain_scores_gemma":[0.9998664,0.00004138964,0.00002597538,0.00001629313,0.00002470501,0.00002524935],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002001187,0.0000118273,0.0000758764,0.00003076808,0.000004610247,0.00005756743,0.00002476794,0.00006038593,0.9988845,0.00009439198,0.00002271922,0.0005324211],"study_design_scores_gemma":[0.000007106308,0.0001296566,0.0006579215,0.000001486691,0.000005570474,0.00008317316,0.00001056182,0.0004654261,0.9983656,0.00004400512,0.0002278068,0.000001661335],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915609,0.001663625,0.005495214,0.0001156357,0.00003762215,0.00002229913,0.0001115093,0.0001062561,0.0008869427],"genre_scores_gemma":[0.997042,0.0004584481,0.0009513717,0.00001706655,0.000008697229,0.00001229361,0.0001446735,0.000008613906,0.001356739],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001145898,"threshold_uncertainty_score":0.003833413,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03336841357396643,"score_gpt":0.2715345796879525,"score_spread":0.2381661661139861,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}