{"id":"W1972178925","doi":"10.1016/j.cellsig.2007.12.004","title":"PI(3,4,5)P3 and PI(3,4)P2 levels correlate with PKB/akt phosphorylation at Thr308 and Ser473, respectively; PI(3,4)P2 levels determine PKB activity","year":2007,"lang":"en","type":"article","venue":"Cellular Signalling","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":122,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; Vancouver Coastal Health; University of British Columbia; Vancouver Coastal Health Research Institute","funders":"Canadian Institutes of Health Research","keywords":"Phosphorylation; Pi; Protein kinase B; Second messenger system; PI3K/AKT/mTOR pathway; Signal transduction; Cytosol; Cell biology; Biology; Chemistry; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001421,0.0006233057,0.0003178962,0.001314477,0.0004668576,0.001113171,0.0002332014,0.0004657801,0.003983558],"category_scores_gemma":[0.0002618546,0.0003826622,0.00030943,0.0008524635,0.0005446334,0.0006888191,0.0002929958,0.001052406,0.001254882],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001009042,"about_ca_system_score_gemma":0.000398477,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002742607,"about_ca_topic_score_gemma":0.003330046,"domain_scores_codex":[0.9997836,0.00001951523,0.00001391653,0.00004855151,0.00005856168,0.00007593296],"domain_scores_gemma":[0.9998286,0.00002369945,0.00004099024,0.00001393775,0.00002855174,0.00006411179],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009298788,0.00006707595,0.002017836,0.00006018806,0.00002964164,0.0001794157,0.00004936291,0.0001600927,0.9906428,0.0006393164,0.0003721248,0.004852264],"study_design_scores_gemma":[0.0000400132,0.000142696,0.04179223,0.000006478578,0.00002766705,0.0006320631,0.00009442853,0.0006937997,0.9519259,0.0007999648,0.003830328,0.00001443701],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9551603,0.009465044,0.01406924,0.0007098197,0.0001296327,0.00006715208,0.0045589,0.0009921277,0.01484787],"genre_scores_gemma":[0.9755549,0.002418057,0.007368246,0.0001419712,0.00004356115,0.0000956693,0.003274219,0.0001162464,0.01098718],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003983558,"threshold_uncertainty_score":0.01332635,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02288820753016635,"score_gpt":0.2500839482579181,"score_spread":0.2271957407277518,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}