{"id":"W1972178925","doi":"10.1016/j.cellsig.2007.12.004","title":"PI(3,4,5)P3 and PI(3,4)P2 levels correlate with PKB/akt phosphorylation at Thr308 and Ser473, respectively; PI(3,4)P2 levels determine PKB activity","year":2007,"lang":"en","type":"article","venue":"Cellular Signalling","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":122,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; Vancouver Coastal Health; University of British Columbia; Vancouver Coastal Health Research Institute","funders":"Canadian Institutes of Health Research","keywords":"Phosphorylation; Pi; Protein kinase B; Second messenger system; PI3K/AKT/mTOR pathway; Signal transduction; Cytosol; Cell biology; Biology; Chemistry; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001098139,0.0006354218,0.0005322665,0.0001514152,0.0004879607,0.0001168303,0.0002921514,0.0005307649,0.0001134641],"category_scores_gemma":[0.00009376535,0.000617136,0.000130214,0.0002553953,0.0003730796,0.00005034665,0.0002964943,0.0004693325,0.00001477139],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001927771,"about_ca_system_score_gemma":0.000162744,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008034617,"about_ca_topic_score_gemma":0.0001760222,"domain_scores_codex":[0.9967232,0.0001457488,0.0005244999,0.001294177,0.0004800059,0.0008324218],"domain_scores_gemma":[0.9982271,0.0001741446,0.0004228094,0.0005763276,0.0002558822,0.0003437192],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001039314,0.00007727913,0.005951693,0.00007881,0.0001909259,0.0001060408,0.0003882865,0.000528769,0.9852406,0.00003403468,0.00006851338,0.006295725],"study_design_scores_gemma":[0.001923704,0.0008013864,0.009970186,0.0001737295,0.000149716,0.0001168181,0.0001018531,0.001693026,0.9810118,0.0001976026,0.002974675,0.0008855143],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9027001,0.005164697,0.09050898,0.00006055098,0.0002683,0.0005211717,0.00006264059,0.00006658134,0.0006470155],"genre_scores_gemma":[0.9949806,0.000223965,0.002593293,0.0001536085,0.0004622578,0.00002605671,0.00007074259,0.0001350181,0.001354411],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09228059,"threshold_uncertainty_score":0.999628,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02288820753016635,"score_gpt":0.2500839482579181,"score_spread":0.2271957407277518,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}