{"id":"W1972194765","doi":"10.1159/000076629","title":"Repression of Gonadotropin-Releasing Hormone (GnRH) Gene Expression by Melatonin May Involve Transcription Factors COUP-TFI and C/EBP Beta Binding at the GnRH Enhancer","year":2004,"lang":"en","type":"article","venue":"Neuroendocrinology","topic":"Circadian rhythm and melatonin","field":"Neuroscience","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University Health Network; University of Toronto","funders":"","keywords":"Enhancer; Melatonin; Gonadotropin-releasing hormone; Transcription factor; Melatonin receptor; Internal medicine; Biology; Electrophoretic mobility shift assay; Endocrinology; Receptor; Chemistry; Cell biology; Molecular biology; Gene; Hormone; Genetics; Luteinizing hormone; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009845918,0.0002406234,0.0001631551,0.0001370537,0.000143033,0.0002304494,0.0001185973,0.0001516465,0.001166626],"category_scores_gemma":[0.0001180429,0.0001379826,0.0003129862,0.00006003207,0.000237974,0.000118909,0.0001503152,0.0003114099,0.0002343015],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002339348,"about_ca_system_score_gemma":0.0001905483,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000812199,"about_ca_topic_score_gemma":0.001597941,"domain_scores_codex":[0.9999188,0.00001127857,0.000007106091,0.00001996466,0.00002115458,0.00002166191],"domain_scores_gemma":[0.9999003,0.00002196439,0.00003262507,0.00001001133,0.00001493303,0.00002014995],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004385778,0.000004282737,0.0006650081,0.00002269285,0.000004622522,0.00005877047,0.00001624509,0.00001927211,0.998399,0.00007163385,0.00001202237,0.0006826914],"study_design_scores_gemma":[0.00003070855,0.0004180773,0.07995722,0.00002411694,0.00003242106,0.0004513002,0.0001358506,0.0008734727,0.9152368,0.0001526775,0.002677273,0.00001017857],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910113,0.002249625,0.004085998,0.0001253708,0.00004660305,0.00001981894,0.0001864934,0.00007832712,0.00219666],"genre_scores_gemma":[0.9949636,0.0009108707,0.001876707,0.00006363213,0.00002027654,0.00002039391,0.000264722,0.00001168143,0.001868005],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001166626,"threshold_uncertainty_score":0.003902733,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0266144215818937,"score_gpt":0.2543369072822914,"score_spread":0.2277224857003977,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}