{"id":"W1972198385","doi":"10.1016/j.molimm.2015.01.015","title":"Circulating TNF and mitochondrial DNA are major determinants of neutrophil phenotype in the advanced-age, frail elderly","year":2015,"lang":"en","type":"article","venue":"Molecular Immunology","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":61,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University Medical Centre; McMaster University","funders":"Institute of Infection and Immunity; Canadian Institutes of Health Research; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University; Canadian Thoracic Society; Joanne G. and Gary N. Owen Fund in Immunology Research; Children's Fund for Glycogen Storage Disease Research","keywords":"Tumor necrosis factor alpha; Inflammation; Immunology; Integrin alpha M; Ex vivo; In vivo; Phenotype; Innate immune system; Biology; Cytokine; Mitochondrial DNA; Immune system; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002454924,0.0002853998,0.000551597,0.0001812016,0.0001113889,0.00001649134,0.0004506484,0.0003357948,0.00003387822],"category_scores_gemma":[0.0001913393,0.0002257823,0.000090013,0.0002491205,0.0004086867,0.00009820619,0.0001940347,0.0004608392,0.0000593693],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003521284,"about_ca_system_score_gemma":0.00006852136,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001194239,"about_ca_topic_score_gemma":0.00008965486,"domain_scores_codex":[0.997855,0.0006626226,0.0004758102,0.0004456693,0.00007090181,0.0004899762],"domain_scores_gemma":[0.9989445,0.0001168485,0.0002719371,0.0005323786,0.0001087786,0.00002557204],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002710563,0.0001107037,0.000767649,0.00001661534,0.00009125603,0.0004867621,0.0009396283,0.000009326283,0.9866675,0.001574929,0.00005048776,0.009014085],"study_design_scores_gemma":[0.008175643,0.001744169,0.0231339,0.0001378755,0.0001182089,0.0006922765,0.003083792,0.000005785522,0.9516252,0.005679536,0.005027433,0.0005761259],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991484,0.006560009,0.0002424925,0.0002990483,0.0006909366,0.0004037907,0.00001455482,0.00002885143,0.0002762751],"genre_scores_gemma":[0.9989793,0.00004617453,0.0004008093,0.0003444513,0.00002757315,0.0000545653,0.00002944257,0.00003062106,0.00008705023],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03504224,"threshold_uncertainty_score":0.9207134,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01793545717965427,"score_gpt":0.2478771012803293,"score_spread":0.2299416441006751,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}