{"id":"W1972198385","doi":"10.1016/j.molimm.2015.01.015","title":"Circulating TNF and mitochondrial DNA are major determinants of neutrophil phenotype in the advanced-age, frail elderly","year":2015,"lang":"en","type":"article","venue":"Molecular Immunology","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":61,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University Medical Centre; McMaster University","funders":"Institute of Infection and Immunity; Canadian Institutes of Health Research; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University; Canadian Thoracic Society; Joanne G. and Gary N. Owen Fund in Immunology Research; Children's Fund for Glycogen Storage Disease Research","keywords":"Tumor necrosis factor alpha; Inflammation; Immunology; Integrin alpha M; Ex vivo; In vivo; Phenotype; Innate immune system; Biology; Cytokine; Mitochondrial DNA; Immune system; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002271284,0.0002934,0.0003957917,0.0004075766,0.0001772702,0.0003616447,0.0001684175,0.0003691102,0.0008431592],"category_scores_gemma":[0.001013312,0.0001582058,0.0001411975,0.0003251394,0.0001800371,0.0002676683,0.0002088225,0.0002969475,0.0001433013],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001122311,"about_ca_system_score_gemma":0.0001101043,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001145777,"about_ca_topic_score_gemma":0.001238994,"domain_scores_codex":[0.999909,0.00001918853,0.00001143413,0.00001896465,0.00002257333,0.00001886786],"domain_scores_gemma":[0.9994337,0.00007345805,0.0002815197,0.00002285984,0.00006928421,0.0001190664],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001749739,0.00007478659,0.9812155,0.00003110044,0.00005339336,0.0003645379,0.0001353042,0.0000529533,0.01151713,0.00002565127,0.0000880321,0.004691734],"study_design_scores_gemma":[0.000008459131,0.0003584055,0.9981853,0.000005289219,0.00002922735,0.0006068858,0.0001359161,0.0001379155,0.000415851,0.00003518505,0.00007885096,0.000002743576],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992989,0.0004342455,0.00008094791,0.00001644134,0.000003901488,0.000001970634,0.0000537124,0.00000155335,0.0001083217],"genre_scores_gemma":[0.9994598,0.0001553939,0.00008735067,0.00001830589,0.0000142642,0.000002176549,0.00008607371,7.69131e-7,0.0001757004],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001145777,"threshold_uncertainty_score":0.002820671,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01793545717965427,"score_gpt":0.2478771012803293,"score_spread":0.2299416441006751,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}