{"id":"W1972200798","doi":"10.1016/j.mehy.2007.01.050","title":"Hereditary cancer gene hunting. A phase of declining success?","year":2007,"lang":"en","type":"article","venue":"Medical Hypotheses","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency","funders":"Revolution Medicines","keywords":"Cancer; Gene; Identification (biology); Allele; Genetics; Biology; Ecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006273892,0.0001107673,0.0001566939,0.00005001602,0.00004822464,0.000006018509,0.0002600167,0.0001810988,0.0006112921],"category_scores_gemma":[0.000906049,0.0001003523,0.00007395769,0.0001308149,0.0002273128,0.000003246688,0.00009329094,0.0001079115,0.000005489047],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002527744,"about_ca_system_score_gemma":0.0003530126,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001413239,"about_ca_topic_score_gemma":0.0003432593,"domain_scores_codex":[0.9987679,0.00003181602,0.0003303114,0.0002536063,0.0003636619,0.0002527462],"domain_scores_gemma":[0.9993036,0.0001062976,0.0001066745,0.0002406255,0.000101517,0.0001412798],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004640885,0.0006181124,0.05025011,0.0001096611,0.0003266647,0.0001144194,0.0003251674,0.00007523646,0.4730228,0.00006752655,0.009061708,0.4655645],"study_design_scores_gemma":[0.00139081,0.0002337988,0.005605287,0.00007421841,0.00003572568,0.00003747367,0.000161459,0.00009654951,0.9307719,0.00009627637,0.06129486,0.0002015968],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870088,0.004419025,0.006160705,0.0003318883,0.0004466657,0.00008372489,0.00002838473,0.0000138313,0.001506962],"genre_scores_gemma":[0.9949898,0.0003477623,0.002574651,0.0007549002,0.001071232,0.00001892704,0.00002808972,0.00002384325,0.0001908381],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4653629,"threshold_uncertainty_score":0.669322,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03370943495263225,"score_gpt":0.3618548974159744,"score_spread":0.3281454624633422,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}