{"id":"W1972200798","doi":"10.1016/j.mehy.2007.01.050","title":"Hereditary cancer gene hunting. A phase of declining success?","year":2007,"lang":"en","type":"article","venue":"Medical Hypotheses","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency","funders":"Revolution Medicines","keywords":"Cancer; Gene; Identification (biology); Allele; Genetics; Biology; Ecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01064872,0.0004727305,0.0008900032,0.002424339,0.002714718,0.006897476,0.002266077,0.007817819,0.0096363],"category_scores_gemma":[0.02078455,0.0003050158,0.0003350188,0.00128142,0.02041825,0.01038554,0.002978588,0.00906052,0.001620098],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003199853,"about_ca_system_score_gemma":0.004209975,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003072143,"about_ca_topic_score_gemma":0.004162605,"domain_scores_codex":[0.9983045,0.0005433692,0.0001257062,0.0002473712,0.0004783428,0.000300803],"domain_scores_gemma":[0.9802526,0.008219252,0.002183271,0.001173204,0.003679728,0.004491866],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.001363369,0.0005655731,0.05190444,0.00112897,0.0001929555,0.004462395,0.004682987,0.001145567,0.004188258,0.5780469,0.1392205,0.2130981],"study_design_scores_gemma":[0.0003054409,0.0006422799,0.05282474,0.001072063,0.00009781265,0.004554065,0.02013867,0.001000413,0.001041589,0.58425,0.3338747,0.0001982395],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.02383082,0.03885426,0.001345342,0.9200357,0.001923064,0.00001970991,0.0001626877,0.00006322015,0.01376521],"genre_scores_gemma":[0.6570429,0.0968786,0.003262144,0.203207,0.02386608,0.0001425255,0.0004756092,0.0001093166,0.01501582],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.01064872,"threshold_uncertainty_score":0.05631644,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03370943495263225,"score_gpt":0.3618548974159744,"score_spread":0.3281454624633422,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}