{"id":"W1972210149","doi":"10.1016/j.ymgme.2009.05.002","title":"Mutation detection in DNA isolated from cerebrospinal fluid and urine: Clinical utility and pitfalls of multiple displacement amplification","year":2009,"lang":"en","type":"article","venue":"Molecular Genetics and Metabolism","topic":"Metabolism and Genetic Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Cerebral Spinal Fluid; Cerebrospinal fluid; Urine; Identification (biology); Mutation; Displacement (psychology); DNA; Multiple displacement amplification; Medicine; Biology; Pathology; Polymerase chain reaction; Genetics; Internal medicine; Gene; DNA extraction; Biomedical engineering; Psychology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003571505,0.001062707,0.0006580242,0.002850572,0.0005161397,0.0009164949,0.001600237,0.00258137,0.001255673],"category_scores_gemma":[0.01450093,0.0005605919,0.0003550515,0.0007545901,0.002674176,0.001713719,0.0007213249,0.001527614,0.000854879],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003413009,"about_ca_system_score_gemma":0.0004793123,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008006693,"about_ca_topic_score_gemma":0.001030502,"domain_scores_codex":[0.9982205,0.0005351556,0.0002688325,0.0003121696,0.0005044352,0.0001589031],"domain_scores_gemma":[0.9901398,0.007675971,0.0005082805,0.000456477,0.0006798432,0.0005396344],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002035599,0.00029039,0.3375182,0.0005830817,0.0001047676,0.09285857,0.001951384,0.001236657,0.4089612,0.003831725,0.001666028,0.1489624],"study_design_scores_gemma":[0.0001484747,0.00208409,0.09376824,0.0004035849,0.0003243132,0.4732991,0.002343946,0.0236091,0.3852918,0.008435725,0.01017899,0.0001126749],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9227672,0.01284589,0.05065373,0.004325998,0.0003983319,0.0001182894,0.0001854802,0.0005360515,0.008169156],"genre_scores_gemma":[0.9749631,0.002221497,0.02139124,0.0005951088,0.00008479993,0.00003281448,0.00005499884,0.00004726849,0.0006090823],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003571505,"threshold_uncertainty_score":0.01888818,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009197794739890337,"score_gpt":0.2671794398012265,"score_spread":0.2579816450613362,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}