{"id":"W1972219651","doi":"10.1289/ehp.1408614","title":"Prenatal Exposure to Maternal Cigarette Smoking and DNA Methylation: Epigenome-Wide Association in a Discovery Sample of Adolescents and Replication in an Independent Cohort at Birth through 17 Years of Age","year":2014,"lang":"en","type":"article","venue":"Environmental Health Perspectives","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":193,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Université de Sherbrooke; University of Manitoba; University of Toronto; SickKids Foundation; Hospital for Sick Children","funders":"Biotechnology and Biological Sciences Research Council; Economic and Social Research Council; Medical Research Council; Canadian Institutes of Health Research; Wellcome Trust","keywords":"dNaM; Epigenome; DNA methylation; Medicine; Pregnancy; Cigarette smoke; Prenatal exposure; Cohort; Biology; Physiology; Obstetrics; Offspring; Environmental health; Genetics; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004835427,0.00007822769,0.0001477375,0.00005223417,0.00002928976,0.000008154045,0.00004530612,0.00007700496,0.000002885282],"category_scores_gemma":[0.00007667532,0.00009116229,0.00001675367,0.00003948432,0.00003677249,0.00002012412,0.00008019956,0.00005758693,8.893353e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002114997,"about_ca_system_score_gemma":0.00001121818,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002994981,"about_ca_topic_score_gemma":0.000527591,"domain_scores_codex":[0.9989878,0.0001378093,0.0002550875,0.0003342435,0.0001591018,0.0001259413],"domain_scores_gemma":[0.9995568,0.00003109553,0.0001869758,0.0001743743,0.000006028619,0.0000447059],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00006045098,0.00007487422,0.9300834,0.0000344498,0.000009113993,2.209163e-7,0.002433247,0.00008205885,0.0663301,0.00001327192,8.279115e-7,0.0008779874],"study_design_scores_gemma":[0.0004249531,0.0003660047,0.9532877,0.0000429656,0.000003571642,1.773158e-7,0.0004801206,0.000008802234,0.04511213,0.0001645651,0.00003664383,0.0000723786],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977826,0.00117251,0.0005827064,0.0000694898,0.00001691063,0.0003028995,0.0000591941,0.000001602851,0.00001207841],"genre_scores_gemma":[0.9986383,0.0007494563,0.0004100211,0.00005207984,0.00002470468,0.00001354477,0.00008193687,0.0000101047,0.00001981806],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02320429,"threshold_uncertainty_score":0.371749,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008634924520700225,"score_gpt":0.2642594751964063,"score_spread":0.2556245506757061,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}