{"id":"W1972237718","doi":"10.1021/bi0502442","title":"Site-Directed Disulfide Mapping of Residues Contributing to the Ca<sup>2+</sup> and K<sup>+</sup> Binding Pocket of the NCKX2 Na<sup>+</sup>/Ca<sup>2+</sup>-K<sup>+</sup> Exchanger","year":2005,"lang":"en","type":"article","venue":"Biochemistry","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Cysteine; Chemistry; Stereochemistry; Amino acid; Binding site; Peptide sequence; Cytoplasm; Biochemistry; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002191652,0.0003212693,0.0001275699,0.0001394102,0.0001395585,0.0002026899,0.0002636608,0.0002614951,0.0004920048],"category_scores_gemma":[0.0002078849,0.000152576,0.0001981929,0.0001688949,0.000189343,0.0001587729,0.0001580662,0.000380628,0.0001531503],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000213533,"about_ca_system_score_gemma":0.0001853256,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005057267,"about_ca_topic_score_gemma":0.0006721577,"domain_scores_codex":[0.9998957,0.0000318605,0.00001074493,0.00002186234,0.00002412429,0.0000157119],"domain_scores_gemma":[0.9998059,0.00004235899,0.00007801777,0.00002150989,0.00002458216,0.00002762663],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000405986,0.00006599892,0.0009645363,0.00004387219,0.00001716982,0.0001583304,0.00005354867,0.0004281157,0.9952633,0.0002707365,0.00005077531,0.002277579],"study_design_scores_gemma":[0.00003135448,0.0002317571,0.004611993,0.000005107823,0.00003379269,0.0005426349,0.00005782816,0.002356941,0.9901941,0.00009717987,0.001830472,0.000006785546],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962142,0.0002174944,0.002789547,0.00004490768,0.00001299825,0.00002370543,0.0001292932,0.00001373078,0.000554128],"genre_scores_gemma":[0.9930084,0.0003066622,0.005369385,0.00004567051,0.000008577324,0.00001574599,0.0004407008,0.00001473188,0.0007901711],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005057267,"threshold_uncertainty_score":0.001645923,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01164997073740424,"score_gpt":0.2328041443267315,"score_spread":0.2211541735893272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}