{"id":"W1972286280","doi":"10.1021/jo402438w","title":"Ketene Reactions with Tertiary Amines","year":2013,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Synthesis of β-Lactam Compounds","field":"Chemistry","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Chemistry; Tertiary amine; Triethylamine; Ketene; Isopropyl; Stereoselectivity; Stereocenter; Cinchona; Acetonitrile; Amine gas treating; Quinuclidine; Alkylation; Organic chemistry; Catalysis; Diethylamine; Medicinal chemistry; Enantioselective synthesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001896562,0.0001968028,0.0002397678,0.00002024054,0.000118958,0.00005938174,0.0006674153,0.0001013132,0.01326081],"category_scores_gemma":[0.0001972438,0.0001176202,0.00009332452,0.0001187524,0.0001294649,0.000218219,0.00007244915,0.0004832798,0.00006935858],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001140433,"about_ca_system_score_gemma":0.0001006736,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001982889,"about_ca_topic_score_gemma":0.000001873734,"domain_scores_codex":[0.9988144,0.0000169407,0.0004494078,0.0001111058,0.0003720492,0.0002360665],"domain_scores_gemma":[0.9982272,0.0003391695,0.000518209,0.0005302938,0.0002486967,0.0001364395],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003549995,0.00007644264,0.00173798,0.00006337021,0.0001411714,0.00001301238,0.00009063594,0.000003449558,0.9942214,3.222788e-7,0.002991084,0.0006255678],"study_design_scores_gemma":[0.0004117493,0.00001435614,0.001743505,0.0001509533,0.0001317803,0.003097089,0.0007426429,0.0000175347,0.9906456,0.0001117813,0.002767623,0.0001654116],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9850495,0.0003024583,0.00005732267,0.002174336,0.00004776837,0.00002626703,0.000001487215,0.00004037205,0.01230045],"genre_scores_gemma":[0.9948252,0.00008823194,0.0003951736,0.00007603964,0.0006231695,0.000002346307,0.000001398397,0.00004547364,0.003943007],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01319145,"threshold_uncertainty_score":0.9876412,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00602993638454279,"score_gpt":0.1883965249682778,"score_spread":0.182366588583735,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}