{"id":"W1972293873","doi":"10.3390/ijms141223315","title":"Self/Co-Assembling Peptide, EAR8-II, as a Potential Carrier for a Hydrophobic Anticancer Drug Pirarubicin (THP)—Characterization and in-Vitro Delivery","year":2013,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"University of Waterloo; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Peptide; Chemistry; Pirarubicin; In vitro; Drug delivery; Combinatorial chemistry; Hydrophobic effect; In vivo; Self-assembling peptide; Biochemistry; Organic chemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001537342,0.0002083466,0.000167841,0.00007209879,0.00008782375,0.0001316361,0.0001203471,0.0001814361,0.0002775455],"category_scores_gemma":[0.0001289515,0.00008772264,0.0001002747,0.00006465556,0.00011042,0.0001280199,0.0001185038,0.0002152997,0.0001927688],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009424164,"about_ca_system_score_gemma":0.00009244423,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001079264,"about_ca_topic_score_gemma":0.0001787036,"domain_scores_codex":[0.99992,0.00001878697,0.000007035942,0.00001665157,0.00002396427,0.0000135158],"domain_scores_gemma":[0.9999422,0.00001275291,0.00001770525,0.000004871913,0.00001076747,0.00001173699],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001297958,0.000005859757,0.00003907095,0.0000162798,9.273064e-7,0.00002106888,0.000004274336,0.00003712466,0.9995204,0.00001098102,0.000004048157,0.0003268848],"study_design_scores_gemma":[0.000003371045,0.0001550325,0.0004072511,0.000001489134,0.000005383643,0.0001320819,0.000005768281,0.0004705086,0.9981523,0.000004684206,0.0006604987,0.000001679711],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992923,0.0008096043,0.00551256,0.00002887793,0.00001484733,0.00003173723,0.00006892082,0.00002583676,0.0005846524],"genre_scores_gemma":[0.9887294,0.0004841478,0.009435434,0.00002312796,0.000008762217,0.00003708675,0.0001642414,0.00001043221,0.001107378],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0002775455,"threshold_uncertainty_score":0.0009285212,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006900633198200401,"score_gpt":0.262186183689441,"score_spread":0.2552855504912406,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}