{"id":"W1972314927","doi":"10.1021/ml100028g","title":"Vorinostat-Like Molecules as Structural, Stereochemical, and Pharmacological Tools","year":2010,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Vorinostat; Pharmacokinetics; Pharmacology; Inhibitory postsynaptic potential; Chemistry; Alkoxy group; Computational biology; Gene isoform; Biochemistry; Medicine; Histone deacetylase; Histone; Biology; Neuroscience; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001775455,0.0002823445,0.0002161363,0.00002575931,0.0001293704,0.00005563398,0.000369223,0.0002661193,0.0002478576],"category_scores_gemma":[0.000383404,0.0002533422,0.00007080204,0.0000856644,0.0006976761,0.0000102294,0.0002479466,0.0007010367,0.00002023588],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000193225,"about_ca_system_score_gemma":0.00008562388,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002027719,"about_ca_topic_score_gemma":0.00000267106,"domain_scores_codex":[0.9981954,0.00003716233,0.0002575056,0.0006210128,0.000404997,0.0004839877],"domain_scores_gemma":[0.999025,0.00007123819,0.00007802061,0.0003818396,0.00008054018,0.0003633889],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001248064,0.00002268494,0.0005067333,0.00004603537,0.00005041241,0.0001195115,0.00004084732,9.618195e-7,0.9834261,0.000003877622,0.01421249,0.001445512],"study_design_scores_gemma":[0.0007879949,0.00007337317,0.0002814375,0.00001340345,0.00003171794,0.0004711444,0.00005699112,0.00001399216,0.9781439,0.000010447,0.01982875,0.0002868428],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962163,0.0002485828,0.00002022037,0.002261193,0.0002389773,0.000163029,0.00002353065,0.00003043855,0.0007977445],"genre_scores_gemma":[0.9955548,0.00006527407,0.0004507267,0.002437482,0.0009241504,0.00003152572,0.0002028458,0.00003130722,0.0003018767],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005616253,"threshold_uncertainty_score":0.9999919,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01022206523799645,"score_gpt":0.2896440705657516,"score_spread":0.2794220053277551,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}