{"id":"W1972314927","doi":"10.1021/ml100028g","title":"Vorinostat-Like Molecules as Structural, Stereochemical, and Pharmacological Tools","year":2010,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Vorinostat; Pharmacokinetics; Pharmacology; Inhibitory postsynaptic potential; Chemistry; Alkoxy group; Computational biology; Gene isoform; Biochemistry; Medicine; Histone deacetylase; Histone; Biology; Neuroscience; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001437366,0.0003444055,0.0004167427,0.0001795413,0.0001462336,0.0003950708,0.0003439742,0.0001644686,0.00292137],"category_scores_gemma":[0.0002040184,0.0001600066,0.0002612949,0.0002163154,0.0002734663,0.0003721528,0.000191819,0.0005462908,0.0004985931],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002921796,"about_ca_system_score_gemma":0.0002535939,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004637995,"about_ca_topic_score_gemma":0.0007463827,"domain_scores_codex":[0.9999665,0.000009095575,0.000002152015,0.000005090811,0.00001169984,0.000005489643],"domain_scores_gemma":[0.9999557,0.00001833986,0.00001104793,0.000005651335,0.00000383332,0.000005432535],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00141462,0.0003268614,0.001520986,0.001154769,0.000105042,0.0008982862,0.00010397,0.1161479,0.6996375,0.05152013,0.00150111,0.1256689],"study_design_scores_gemma":[0.001001422,0.003449718,0.002961436,0.0001105065,0.0003520233,0.001661281,0.000206731,0.236472,0.6667847,0.01905278,0.06781312,0.0001342222],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8599697,0.01791723,0.07791609,0.0009976063,0.0001670604,0.0003852822,0.002183192,0.001093124,0.03937057],"genre_scores_gemma":[0.9643853,0.007123344,0.02567404,0.0000991114,0.00004375046,0.00006299261,0.0008161259,0.00003247403,0.001762827],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00292137,"threshold_uncertainty_score":0.009772956,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01022206523799645,"score_gpt":0.2896440705657516,"score_spread":0.2794220053277551,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}