{"id":"W1972335962","doi":"10.1021/bi0603827","title":"The Complement Regulator C4b-Binding Protein (C4BP) Interacts with both the C4c and C4dg Subfragments of the Parent C4b Ligand:  Evidence for Synergy in C4BP Subsite Binding","year":2006,"lang":"en","type":"article","venue":"Biochemistry","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Regulator; Chemistry; Ligand (biochemistry); Complement (music); Plasma protein binding; Binding site; Biology; Biochemistry; Receptor; Gene; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004825858,0.0002336713,0.000242937,0.00003342437,0.00044091,0.00005548879,0.0005407031,0.00008290013,0.00002875128],"category_scores_gemma":[0.0001326714,0.0001229544,0.00008810862,0.0001464068,0.0003040306,0.00005534961,0.0002698529,0.0001490787,0.000003191424],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001356902,"about_ca_system_score_gemma":0.00009473693,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002278626,"about_ca_topic_score_gemma":0.0002776454,"domain_scores_codex":[0.9984666,0.0001383962,0.0005029585,0.0003596946,0.0001159792,0.0004164455],"domain_scores_gemma":[0.9984555,0.000473792,0.0004132827,0.0005729993,0.00006238073,0.00002204117],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003302199,0.00009419283,0.04802362,0.0002102907,0.0001130128,0.000001260265,0.0001271749,0.000006946937,0.9485871,0.0001970982,0.002130217,0.0001789082],"study_design_scores_gemma":[0.001212544,0.00007700651,0.02143272,0.001596597,0.00005638303,0.00001751832,0.000915018,0.00001087543,0.9723423,0.00004871713,0.002105977,0.0001843486],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949595,0.002918963,0.00001166148,0.0005869529,0.000157951,0.001180795,0.0001084726,0.00001856486,0.00005717381],"genre_scores_gemma":[0.9981068,0.00001893864,0.00002271012,0.00002304958,0.00004420934,0.0003468099,0.00006628519,0.00001815701,0.001353012],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02659089,"threshold_uncertainty_score":0.5013935,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02442028378017374,"score_gpt":0.271220101959194,"score_spread":0.2467998181790202,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}