{"id":"W1972335962","doi":"10.1021/bi0603827","title":"The Complement Regulator C4b-Binding Protein (C4BP) Interacts with both the C4c and C4dg Subfragments of the Parent C4b Ligand:  Evidence for Synergy in C4BP Subsite Binding","year":2006,"lang":"en","type":"article","venue":"Biochemistry","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Regulator; Chemistry; Ligand (biochemistry); Complement (music); Plasma protein binding; Binding site; Biology; Biochemistry; Receptor; Gene; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000512286,0.0007448451,0.0004706279,0.0003859227,0.0003071308,0.0003157523,0.0004866208,0.0006894161,0.001422825],"category_scores_gemma":[0.0003768395,0.0004142158,0.0005744097,0.0002257689,0.000394015,0.0002146035,0.0006614938,0.0005562739,0.0005488751],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006019974,"about_ca_system_score_gemma":0.0003101081,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002235883,"about_ca_topic_score_gemma":0.001660255,"domain_scores_codex":[0.9992169,0.0001875315,0.00002791121,0.0001425234,0.0002214811,0.0002037382],"domain_scores_gemma":[0.9996758,0.0001114165,0.00004700351,0.00002808866,0.00004358662,0.00009418483],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008830527,0.00001579116,0.0001561767,0.00001380954,0.000006840496,0.00001548079,0.000006684789,0.00002816856,0.9994398,0.00001521921,0.00001047058,0.0002033344],"study_design_scores_gemma":[0.00001881608,0.0003584423,0.008958342,0.000005882405,0.00001993878,0.0002380263,0.00002210981,0.001269125,0.9884325,0.00002987354,0.0006357576,0.00001110705],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964569,0.001098962,0.001772638,0.0000677366,0.000009728332,0.00002053917,0.00007532511,0.00002927538,0.0004688314],"genre_scores_gemma":[0.9942609,0.0003793824,0.003657644,0.0001110477,0.00001156362,0.00003516736,0.0002820148,0.00001795329,0.001244232],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002235883,"threshold_uncertainty_score":0.004759789,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02442028378017374,"score_gpt":0.271220101959194,"score_spread":0.2467998181790202,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}