{"id":"W1972338617","doi":"10.1074/jbc.m402475200","title":"Caspase-mediated Specific Cleavage of Human Histone Deacetylase 4","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"National Cancer Institute","keywords":"Cleavage (geology); Histone deacetylase; Cell biology; HDAC11; Histone deacetylase 5; Chemistry; Histone deacetylase 2; Histone; Biology; Biochemistry; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004616718,0.0002078681,0.000396598,0.00005229446,0.00007343585,0.00001125713,0.0004332291,0.0003992096,0.0001168693],"category_scores_gemma":[0.000408815,0.0001650567,0.0003044134,0.0001573413,0.000455382,0.000005608266,0.0001265307,0.0004323586,0.00001410541],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000131076,"about_ca_system_score_gemma":0.0001736094,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000867009,"about_ca_topic_score_gemma":0.000001838817,"domain_scores_codex":[0.9982818,0.00006203041,0.0007247122,0.0002755303,0.0003342253,0.0003217382],"domain_scores_gemma":[0.9986146,0.00003325228,0.0004763993,0.0003328502,0.0002821722,0.0002607455],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002403091,0.0003369103,0.000175993,0.00003457947,0.00004651842,0.0001501756,0.00002296857,0.00001980108,0.9947457,0.00001069901,0.004059846,0.0001565033],"study_design_scores_gemma":[0.001459273,0.0008112321,0.0004348981,0.00004618123,0.000009491173,0.0003189234,0.00007924045,3.237412e-7,0.9899831,0.00006639038,0.006612399,0.0001785431],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955709,0.001935575,0.0001359192,0.0001341634,0.00008045167,0.00007419377,0.00003285899,0.000007982881,0.002027974],"genre_scores_gemma":[0.9981824,0.0003846626,0.000491755,0.00004736953,0.0005560087,0.000002661918,0.00007876145,0.00001990503,0.0002365166],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004762592,"threshold_uncertainty_score":0.6730815,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.027696021112694,"score_gpt":0.3062608635281548,"score_spread":0.2785648424154608,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}