{"id":"W1972351486","doi":"10.1111/j.1365-2567.2004.01938.x","title":"TLR9<sup>−/−</sup> and TLR9<sup>+/+</sup> mice display similar immune responses to a DNA vaccine","year":2004,"lang":"en","type":"article","venue":"Immunology","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; University of British Columbia; The Metabolomics Innovation Centre","funders":"","keywords":"TLR9; Toll-Like Receptor 9; Immunogenicity; Immune system; DNA vaccination; CpG site; Biology; Adjuvant; Antigen; Immunization; Plasmid; Immunity; Immunology; DNA; Gene; Genetics; DNA methylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001007744,0.0007743706,0.001131909,0.0008216734,0.0007543347,0.00009370153,0.0008489338,0.001071599,0.000735848],"category_scores_gemma":[0.001003715,0.0007310126,0.0002707006,0.0006091293,0.0004691407,0.0005764875,0.0006502998,0.001006,0.003503606],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002470419,"about_ca_system_score_gemma":0.0003019085,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005529629,"about_ca_topic_score_gemma":0.00003194243,"domain_scores_codex":[0.9951129,0.00111579,0.00123885,0.001004801,0.000113385,0.001414249],"domain_scores_gemma":[0.9973115,0.0007553336,0.0003149748,0.001280386,0.0002476592,0.00009009997],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00896448,0.000346214,0.0004715446,0.00004932219,0.001018613,0.0001153895,0.007440947,0.0007692924,0.9671912,0.003100801,0.0016313,0.008900964],"study_design_scores_gemma":[0.01534321,0.003364645,0.0359634,0.0003675511,0.0003736679,0.002969073,0.004615874,0.00009160339,0.6185835,0.001512254,0.3149972,0.001817971],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9722351,0.01769461,0.0003616724,0.007331547,0.0005734544,0.0009259213,0.0000612219,0.0003292425,0.00048717],"genre_scores_gemma":[0.9919698,0.001331881,0.0004162292,0.001113115,0.0001246858,0.0001680202,0.0003180195,0.0001045353,0.004453671],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3486076,"threshold_uncertainty_score":0.9995141,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007269920040347514,"score_gpt":0.2336442565184532,"score_spread":0.2263743364781057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}