{"id":"W1972351486","doi":"10.1111/j.1365-2567.2004.01938.x","title":"TLR9<sup>−/−</sup> and TLR9<sup>+/+</sup> mice display similar immune responses to a DNA vaccine","year":2004,"lang":"en","type":"article","venue":"Immunology","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; University of British Columbia; The Metabolomics Innovation Centre","funders":"","keywords":"TLR9; Toll-Like Receptor 9; Immunogenicity; Immune system; DNA vaccination; CpG site; Biology; Adjuvant; Antigen; Immunization; Plasmid; Immunity; Immunology; DNA; Gene; Genetics; DNA methylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000538849,0.001397519,0.0005888085,0.00167105,0.0003537017,0.0008961833,0.0004756464,0.001521748,0.00657788],"category_scores_gemma":[0.0002764935,0.0005756148,0.0006719986,0.0002722496,0.001205397,0.0007727838,0.0004315908,0.002710563,0.001870003],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003936217,"about_ca_system_score_gemma":0.000221171,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002462089,"about_ca_topic_score_gemma":0.0003519323,"domain_scores_codex":[0.9992404,0.0001444586,0.0001225388,0.000173211,0.000152778,0.0001665643],"domain_scores_gemma":[0.9986531,0.000160163,0.0005757097,0.0001565476,0.00006317988,0.0003912876],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001025355,0.0004340956,0.0003692755,0.00006907809,0.0000180613,0.0001355319,0.0000288267,0.0001168257,0.9960956,0.0005545618,0.0001342729,0.001018577],"study_design_scores_gemma":[0.0002934816,0.002996175,0.006102908,0.00004034828,0.00005352226,0.001966394,0.0001319419,0.001396425,0.9822384,0.0006357657,0.004115391,0.00002930597],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986134,0.0007168152,0.006235789,0.0005916783,0.000130355,0.0001432186,0.00247007,0.0003388902,0.003239123],"genre_scores_gemma":[0.9554964,0.001079974,0.0123433,0.0008079595,0.000125557,0.0005066403,0.005210384,0.0003702403,0.02405966],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00657788,"threshold_uncertainty_score":0.0220052,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007269920040347514,"score_gpt":0.2336442565184532,"score_spread":0.2263743364781057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}