{"id":"W1972372858","doi":"10.1038/leu.2014.150","title":"Dominant-negative Ikaros cooperates with BCR-ABL1 to induce human acute myeloid leukemia in xenografts","year":2014,"lang":"en","type":"article","venue":"Leukemia","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; Hospital for Sick Children; Princess Margaret Cancer Centre; University of Toronto; Ontario Institute for Cancer Research","funders":"Canadian Institutes of Health Research","keywords":"Cancer research; Myeloid leukemia; Myeloid; Biology; Progenitor cell; Leukemia; Haematopoiesis; Immunology; Stem cell; Transplantation; Medicine; Cell biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006509018,0.0006079473,0.0006676233,0.0006252636,0.0004624953,0.0009005055,0.0005135486,0.0005267582,0.002293521],"category_scores_gemma":[0.0002539413,0.0003501983,0.0005252861,0.0005740681,0.0004434494,0.0005394159,0.0003151318,0.002123853,0.000732958],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009197092,"about_ca_system_score_gemma":0.000635091,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001874909,"about_ca_topic_score_gemma":0.002349824,"domain_scores_codex":[0.9994235,0.0001097288,0.00005495976,0.00007896873,0.0001452938,0.0001874898],"domain_scores_gemma":[0.9996214,0.0001248396,0.00006903615,0.00007582962,0.00002495807,0.00008398762],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006138044,0.0005830895,0.0002986168,0.00006060777,0.00002668936,0.0001164286,0.00008843173,0.0005559001,0.9944127,0.001122228,0.0005377776,0.00158364],"study_design_scores_gemma":[0.000255311,0.001155457,0.0021221,0.000007206188,0.00003983332,0.0003078114,0.00009726101,0.003997413,0.9874952,0.0001825713,0.004332361,0.000007446461],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892274,0.00130063,0.002833294,0.0004202318,0.0001483848,0.0001712481,0.001729466,0.000305737,0.003863583],"genre_scores_gemma":[0.9938315,0.0004796631,0.001382997,0.00005482311,0.00001841449,0.00009811798,0.001314857,0.00005081321,0.002768783],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002293521,"threshold_uncertainty_score":0.007672608,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01375171160497574,"score_gpt":0.2871761525076483,"score_spread":0.2734244409026726,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}