{"id":"W1972404314","doi":"10.1007/s12031-015-0567-9","title":"Preliminary Transcriptome Analysis in Lymphoblasts from Cluster Headache and Bipolar Disorder Patients Implicates Dysregulation of Circadian and Serotonergic Genes","year":2015,"lang":"en","type":"article","venue":"Journal of Molecular Neuroscience","topic":"Circadian rhythm and melatonin","field":"Neuroscience","cited_by":44,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"","keywords":"Biology; Serotonergic; Microarray analysis techniques; Bipolar disorder; Transcriptome; Fold change; Gene; Gene expression profiling; Circadian rhythm; Gene expression; Internal medicine; Endocrinology; Genetics; Medicine; Receptor; Serotonin; Lithium (medication)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002865161,0.0001550218,0.0003263309,0.0005638453,0.00005255942,0.00005587835,0.000224502,0.00007025836,0.000001935304],"category_scores_gemma":[0.0002470902,0.0001383188,0.00009273554,0.0009289332,0.0002645981,0.0004420629,0.00006474907,0.0001360779,4.951157e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003509326,"about_ca_system_score_gemma":0.00007891995,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006110362,"about_ca_topic_score_gemma":0.00001099105,"domain_scores_codex":[0.9982015,0.0002085403,0.0004921615,0.00036956,0.0004933988,0.0002348642],"domain_scores_gemma":[0.9990288,0.00008376589,0.0003292362,0.0001923069,0.00008654797,0.0002793157],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00009964585,0.0001283454,0.3028573,0.00001267045,0.000006595053,0.00004577811,0.0007988666,0.002973302,0.6898201,0.00006053382,0.000003342939,0.00319349],"study_design_scores_gemma":[0.001342445,0.0004540485,0.7946364,0.0000289033,0.0000926803,0.00008263542,0.00005257826,0.009360678,0.1933778,0.000146842,0.000272772,0.0001522489],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995724,0.002640362,0.001055627,0.000250355,0.0001187836,0.0001787944,0.00001670129,0.000005081507,0.00001026672],"genre_scores_gemma":[0.9992064,0.0002440461,0.0001501466,0.0003624319,0.00001255294,0.000002807598,9.878253e-7,0.00001292301,0.000007714177],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4964423,"threshold_uncertainty_score":0.5640476,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01652138099035675,"score_gpt":0.2440677847350551,"score_spread":0.2275464037446984,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}