{"id":"W1972406166","doi":"10.4161/onci.27156","title":"An allogeneic NK cell line engineered to express chimeric antigen receptors","year":2013,"lang":"en","type":"article","venue":"OncoImmunology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Cancer Research; Labex Immuno-Oncology; Institut National Du Cancer; Ligue Contre le Cancer; Agence Nationale de la Recherche","keywords":"Cytotoxic T cell; Chimeric antigen receptor; Antigen; Interleukin 21; NK-92; Biology; Antibody; Antibody-dependent cell-mediated cytotoxicity; Adoptive cell transfer; Immunology; Natural killer T cell; Immunotherapy; Cancer research; T cell; Monoclonal antibody; Immune system; CD8; In vitro","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.00020173,0.0002465083,0.0004868985,0.0003234044,0.00006957415,0.0000269164,0.0003924496,0.0002545913,0.01896401],"category_scores_gemma":[0.00005814652,0.0002226548,0.0001051892,0.0004229115,0.0001154706,0.00009854436,0.0001154558,0.0004117823,0.002330753],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001300145,"about_ca_system_score_gemma":0.0001250207,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007395365,"about_ca_topic_score_gemma":0.00001159404,"domain_scores_codex":[0.9981476,0.0001463564,0.0003209213,0.0004647001,0.0002405086,0.0006799087],"domain_scores_gemma":[0.9984626,0.00007787259,0.00005395688,0.0009604993,0.0001577222,0.0002873737],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000198124,0.0003082196,0.001612153,0.00002095328,0.00008855081,0.00001905537,0.0005558314,0.00003493699,0.941137,0.000008708781,0.003298184,0.05271833],"study_design_scores_gemma":[0.002719957,0.004420966,0.04387355,0.00004256663,0.0000363462,0.0001059207,0.0004325612,0.0002761055,0.6132514,0.00003724426,0.3343437,0.0004597104],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902543,0.001443794,0.0003408078,0.001487744,0.000501277,0.0009762394,0.000004683691,0.0001822587,0.004808906],"genre_scores_gemma":[0.9675925,0.0009275301,0.004300886,0.001040672,0.0003937714,0.0002177354,0.0001079827,0.0001042972,0.02531461],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3310455,"threshold_uncertainty_score":0.998446,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01922988873651518,"score_gpt":0.2991261395650586,"score_spread":0.2798962508285434,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}