{"id":"W1972450594","doi":"10.1371/journal.pone.0061765","title":"The Calmodulin-Binding, Short Linear Motif, NSCaTE Is Conserved in L-Type Channel Ancestors of Vertebrate Cav1.2 and Cav1.3 Channels","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada; Heart and Stroke Foundation of Canada","keywords":"Calmodulin; Biology; Lymnaea stagnalis; EF hand; Voltage-dependent calcium channel; Calcium-binding protein; Calcium; Cav1.2; Calcium channel; EGTA; Biochemistry; Cell biology; Biophysics; Chemistry; Snail; Protein subunit; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008866337,0.0002797417,0.0003484552,0.0002240021,0.000289301,0.0002387096,0.0002310035,0.0002922982,0.001046209],"category_scores_gemma":[0.0002996606,0.0001268691,0.0003346852,0.0002146692,0.000356082,0.000242741,0.0002937411,0.0004544216,0.0006714733],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002757498,"about_ca_system_score_gemma":0.0002571408,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004554359,"about_ca_topic_score_gemma":0.0009124468,"domain_scores_codex":[0.9998924,0.000007635702,0.000009139313,0.00004988043,0.00002715117,0.00001376],"domain_scores_gemma":[0.9997932,0.0000147341,0.00007679648,0.00001685964,0.00003375288,0.00006476107],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000132503,0.0000121561,0.001320383,0.00007607068,0.00001163343,0.0002548636,0.00003070636,0.00007151416,0.9922341,0.0003237933,0.0001797883,0.005352558],"study_design_scores_gemma":[0.000175137,0.000985964,0.142711,0.0000605262,0.0001287572,0.008016274,0.00008982138,0.003762192,0.7667958,0.001082037,0.07612237,0.00007014155],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9667954,0.004434368,0.02189685,0.0002456037,0.0002034263,0.0001464434,0.001406463,0.0006900697,0.004181377],"genre_scores_gemma":[0.9789793,0.001022794,0.01364078,0.0002631194,0.00006767351,0.00009262055,0.001813489,0.00007251867,0.004047653],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001046209,"threshold_uncertainty_score":0.003499925,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04760799023502032,"score_gpt":0.2393865530544992,"score_spread":0.1917785628194789,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}