{"id":"W1972450594","doi":"10.1371/journal.pone.0061765","title":"The Calmodulin-Binding, Short Linear Motif, NSCaTE Is Conserved in L-Type Channel Ancestors of Vertebrate Cav1.2 and Cav1.3 Channels","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada; Heart and Stroke Foundation of Canada","keywords":"Calmodulin; Biology; Lymnaea stagnalis; EF hand; Voltage-dependent calcium channel; Calcium-binding protein; Calcium; Cav1.2; Calcium channel; EGTA; Biochemistry; Cell biology; Biophysics; Chemistry; Snail; Protein subunit; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001660461,0.000129129,0.0001694149,0.00005163976,0.00009014062,0.00002073828,0.00009940436,0.0001398959,0.00003125044],"category_scores_gemma":[0.00008074993,0.000104249,0.00003576087,0.0001302752,0.0001071146,0.000009108971,0.00005619056,0.0000862333,0.00002147918],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001219764,"about_ca_system_score_gemma":0.00003275744,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001216731,"about_ca_topic_score_gemma":0.00005142893,"domain_scores_codex":[0.9991139,0.0000476612,0.0002354264,0.0002491823,0.0001452391,0.0002086606],"domain_scores_gemma":[0.9994317,0.00001559046,0.00007271764,0.0002151108,0.0001942579,0.00007057373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003459803,0.0006344423,0.0249831,0.0001575401,0.000341543,0.000002175994,0.0007261771,0.0003535023,0.9669699,0.00004527143,0.004247387,0.001192959],"study_design_scores_gemma":[0.0007407718,0.0004527417,0.00892518,0.00009195923,0.00003993187,0.000003697409,0.000250192,0.04063833,0.9472783,0.0001505535,0.001151082,0.0002773149],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979232,0.0006517208,0.00002969366,0.0005803939,0.0002997168,0.0003155375,0.00000975628,0.000009804326,0.0001802036],"genre_scores_gemma":[0.9967046,0.0007061503,0.00005567919,0.0001377182,0.0002438161,0.00003444911,0.0000490552,0.00001846033,0.002050115],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04028483,"threshold_uncertainty_score":0.4251151,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04760799023502032,"score_gpt":0.2393865530544992,"score_spread":0.1917785628194789,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}