{"id":"W197246149","doi":"10.1007/978-1-62703-478-4_11","title":"Histone Modification Profiling in Normal and Transformed Human Embryonic Stem Cells Using Micro Chromatin Immunoprecipitation, Scalable to Genome-Wide Microarray Analyses","year":2013,"lang":"en","type":"article","venue":"Methods in molecular biology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Population Health Research Institute","funders":"","keywords":"Biology; Epigenetics; Chromatin immunoprecipitation; Embryonic stem cell; Induced pluripotent stem cell; Histone; Somatic cell; Computational biology; Microarray; Cancer stem cell; Stem cell; Cell biology; Genetics; Gene; Gene expression; Promoter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001890075,0.0001337066,0.0001825536,0.000360339,0.0001419661,0.0003753928,0.0001718545,0.0001507612,0.0008927623],"category_scores_gemma":[0.0002023859,0.0001395517,0.0001799269,0.000304167,0.0001423689,0.0001383898,0.0001838142,0.0003040281,0.0003411861],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001937491,"about_ca_system_score_gemma":0.0001396217,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005123844,"about_ca_topic_score_gemma":0.001590138,"domain_scores_codex":[0.9998263,0.00001580076,0.00001626707,0.0000569763,0.00006356481,0.00002120473],"domain_scores_gemma":[0.9999163,0.00003410905,0.000009280892,0.00001215853,0.00001766341,0.00001044749],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004196188,0.00000743122,0.0006119343,0.0000142579,0.000005324953,0.000007723032,0.00001536774,0.0001081818,0.9971372,0.00006996399,0.00002899892,0.001951727],"study_design_scores_gemma":[0.000005466124,0.00007973192,0.02479125,0.000002307749,0.00002078205,0.00007158393,0.00004521192,0.00256894,0.9708343,0.0001689843,0.001403396,0.000007963773],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.9483175,0.0008932472,0.04307357,0.0001303068,0.00003550937,0.00007402906,0.004678091,0.000371961,0.002425835],"genre_scores_gemma":[0.949656,0.001009384,0.03850842,0.0002614807,0.000016263,0.0002379688,0.006270347,0.00008519091,0.003954813],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.0008927623,"threshold_uncertainty_score":0.00298655,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04021347936847962,"score_gpt":0.3958154576430895,"score_spread":0.3556019782746098,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}