{"id":"W1972477161","doi":"10.1021/bi2014618","title":"Structure of the 2-Aminopurine-Cytosine Base Pair Formed in the Polymerase Active Site of the RB69 Y567A-DNA Polymerase","year":2011,"lang":"en","type":"article","venue":"Biochemistry","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research","keywords":"DNA polymerase; Base pair; Polymerase; DNA clamp; Primer (cosmetics); Cytosine; Biology; DNA polymerase II; DNA; Biochemistry; Molecular biology; Chemistry; Stereochemistry; Polymerase chain reaction; Reverse transcriptase; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000139302,0.0002645566,0.0002076688,0.00002369865,0.00007925013,0.000007141369,0.0008375008,0.0002635822,0.00007809273],"category_scores_gemma":[0.0001680218,0.0001461783,0.0002539454,0.0002537226,0.0002820188,0.000005924057,0.0003441084,0.0002097276,8.081766e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002242631,"about_ca_system_score_gemma":0.0001852666,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001416194,"about_ca_topic_score_gemma":0.0000628617,"domain_scores_codex":[0.9985738,0.0001214533,0.0003494275,0.0003683684,0.0002912547,0.0002956494],"domain_scores_gemma":[0.9981847,0.00002521172,0.000312269,0.001344582,0.00007539204,0.00005788376],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001722483,0.0001557347,0.003631469,0.0000675269,0.00004763911,0.000002803851,0.0003811053,9.14752e-7,0.9947944,0.00003423746,0.0003544577,0.0003574175],"study_design_scores_gemma":[0.0006286071,0.00007838693,0.008217625,0.00004660097,0.00004797784,0.00003239881,0.0004511605,0.00001014273,0.9901199,0.0001046049,0.00009197755,0.0001706603],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978961,0.0004245651,0.00001026515,0.0002057364,0.000128972,0.0003166061,0.0003491176,0.000007910679,0.0006607528],"genre_scores_gemma":[0.9988697,0.00001124245,0.0001165947,0.0003622242,0.0001077737,0.00001787193,0.00005856218,0.00002628985,0.0004297483],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004674589,"threshold_uncertainty_score":0.5960977,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008198770408593792,"score_gpt":0.2028970606566217,"score_spread":0.1946982902480279,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}