{"id":"W1972529932","doi":"10.1016/j.bmc.2010.01.064","title":"Synthesis, radiofluorination, and hypoxia-selective studies of FRAZ: A configurational and positional analogue of the clinical hypoxia marker, [18F]-FAZA","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Cancer Research Institute","keywords":"Radiosynthesis; Chemistry; Nitroimidazole; Radiosensitizer; Hypoxia (environmental); Tumor hypoxia; Nucleoside; Misonidazole; Cytotoxicity; In vitro; Combinatorial chemistry; Nucleoside analogue; In vivo; Stereochemistry; Radiochemistry; Cancer research; Biochemistry; Oxygen; Organic chemistry; Radiation therapy; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005630562,0.00065171,0.0003434753,0.0005514782,0.0005131441,0.0002157916,0.0007611151,0.0004381901,0.001657344],"category_scores_gemma":[0.0004128564,0.0003056597,0.0003091729,0.0004445526,0.0004849811,0.0005008861,0.0002360552,0.000601805,0.0005485255],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005448675,"about_ca_system_score_gemma":0.0006770397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002417905,"about_ca_topic_score_gemma":0.002023873,"domain_scores_codex":[0.9998384,0.00004163639,0.000009025625,0.0000340257,0.00002400055,0.00005296955],"domain_scores_gemma":[0.9997665,0.00005617093,0.00006408275,0.00003354763,0.00004116252,0.00003857429],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000574375,0.00008903947,0.0001103327,0.0001153875,0.00001638689,0.0002447887,0.0001283732,0.0007316634,0.9897388,0.001580513,0.0002386129,0.006431704],"study_design_scores_gemma":[0.00003425491,0.0003137219,0.0002408049,0.000003809388,0.00001481757,0.0003777471,0.000014042,0.0002174317,0.99413,0.00007413739,0.004570274,0.000009003301],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.884101,0.006526002,0.09746638,0.0007030564,0.0001043271,0.0004731996,0.00169646,0.0003053933,0.008624154],"genre_scores_gemma":[0.9482637,0.004548896,0.03756322,0.00009933111,0.0000526464,0.0001606354,0.001904612,0.0001179249,0.00728891],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002417905,"threshold_uncertainty_score":0.005544364,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01581427267615285,"score_gpt":0.2890163825599472,"score_spread":0.2732021098837943,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}