{"id":"W1972538283","doi":"10.1001/jama.2012.7625","title":"Association Between Use of Interferon Beta and Progression of Disability in Patients With Relapsing-Remitting Multiple Sclerosis","year":2012,"lang":"en","type":"article","venue":"JAMA","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":259,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia Hospital; Vancouver Coastal Health Research Institute; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Biogen; Bayer Canada; Multiple Sclerosis Society; Multiple Sclerosis Trust; University of British Columbia; Schweizerische Multiple Sklerose Gesellschaft; Multiple Sclerosis Society of Canada; Michael Smith Health Research BC; Canadian Institutes of Health Research; Ministry of Health, British Columbia; Teva Pharmaceutical Industries; National Multiple Sclerosis Society","keywords":"Medicine; Expanded Disability Status Scale; Interquartile range; Internal medicine; Cohort; Multiple sclerosis; Hazard ratio; Propensity score matching; Proportional hazards model; Cohort study; Interferon beta-1b; Interferon beta-1a; Confounding; Interferon beta; Confidence interval; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007191389,0.00009787763,0.0003540894,0.00006434051,0.00003351474,0.000009542721,0.00003871024,0.00009285512,0.000006083493],"category_scores_gemma":[0.003714985,0.00007008898,0.00003300684,0.0001748772,0.0001407378,0.0003285532,0.0001290678,0.0001930496,5.245714e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002266129,"about_ca_system_score_gemma":0.00001103326,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001855807,"about_ca_topic_score_gemma":0.00003761851,"domain_scores_codex":[0.9986323,0.0001319119,0.0003552234,0.0001555427,0.0004732414,0.0002517555],"domain_scores_gemma":[0.9983437,0.000894727,0.0002601696,0.0001834418,0.0002317989,0.00008615629],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004583194,0.0004453404,0.949299,0.0002062756,0.00007941994,2.615008e-8,0.0007680192,5.03851e-7,0.002118828,7.347754e-7,0.00005556748,0.04656791],"study_design_scores_gemma":[0.003627921,0.0004297936,0.9889844,0.001245565,0.00005034764,2.674755e-8,0.0000939872,0.00004276033,0.005446017,6.599896e-7,0.00002012769,0.00005841432],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990456,0.00006522569,0.000007307122,0.000235413,0.00002145005,0.0005503921,0.00003185124,0.0000110762,0.00003174328],"genre_scores_gemma":[0.9985415,0.00002886454,0.001310361,0.000006257967,0.00004940729,0.00001434895,0.00002640529,0.00001197491,0.00001092393],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0465095,"threshold_uncertainty_score":0.4447453,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07161619887011535,"score_gpt":0.3079049013401406,"score_spread":0.2362887024700253,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}