{"id":"W1972544795","doi":"10.1074/jbc.m112.431486","title":"Adenylosuccinate Synthetase and Adenylosuccinate Lyase Deficiencies Trigger Growth and Infectivity Deficits in Leishmania donovani","year":2013,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Leishmania donovani; Biology; Purine nucleoside phosphorylase; Purine metabolism; Biochemistry; Nucleotide salvage; Auxotrophy; Purine; Mutant; Molecular biology; Enzyme; Nucleotide; Genetics; Gene; Leishmaniasis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000112947,0.0004385185,0.0002278071,0.0002773024,0.0001447519,0.0003236077,0.0002842826,0.0003480102,0.001166972],"category_scores_gemma":[0.0001678053,0.0002779912,0.0002099672,0.0001277861,0.0004193885,0.000149072,0.0003350612,0.000569385,0.0002471714],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000373119,"about_ca_system_score_gemma":0.0001977033,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009883289,"about_ca_topic_score_gemma":0.001503609,"domain_scores_codex":[0.9997819,0.0000357362,0.00002578527,0.00004194121,0.00005229121,0.0000624201],"domain_scores_gemma":[0.9998044,0.00003722126,0.00005298377,0.00001734016,0.00001463176,0.00007333422],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008750557,0.00003671164,0.0002095545,0.00003328055,0.000003289654,0.0001398379,0.00002408038,0.00002937699,0.999024,0.0001032282,0.00002491695,0.0002840653],"study_design_scores_gemma":[0.00004124344,0.0006149482,0.00946959,0.00001342409,0.00001835227,0.0008678824,0.0001362343,0.0009569317,0.9858536,0.0001047714,0.001914712,0.000008415174],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983015,0.0002578381,0.0003360664,0.00006337491,0.0000145114,0.00001448234,0.0002167547,0.00005073514,0.0007446944],"genre_scores_gemma":[0.9970879,0.0001867424,0.000364299,0.00004404947,0.000004044788,0.00002438696,0.0002873414,0.00001783059,0.001983426],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001166972,"threshold_uncertainty_score":0.003903925,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02585398499446086,"score_gpt":0.2715357074296519,"score_spread":0.2456817224351911,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}