{"id":"W1972592088","doi":"10.1021/bi901620v","title":"Structural and Functional Characterization of the Monomeric U-Box Domain from E4B","year":2009,"lang":"en","type":"article","venue":"Biochemistry","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Institute of Environmental Health Sciences; National Institute of General Medical Sciences; National Cancer Institute","keywords":"Monomer; Ubiquitin; Ubiquitin-Protein Ligases; Domain (mathematical analysis); Protein structure; Escherichia coli; Function (biology); Chemistry; Ubiquitin-conjugating enzyme; Biochemistry; Sequence alignment; Sequence (biology); Stereochemistry; Biology; Peptide sequence; Ubiquitin ligase; Cell biology; Gene; Polymer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002124846,0.0002859911,0.0002391538,0.0003121197,0.0003071354,0.0003216922,0.0003904522,0.0003625494,0.00105293],"category_scores_gemma":[0.000405413,0.0002050992,0.0002183043,0.0003008638,0.0001978308,0.0002618406,0.0002175191,0.0004171102,0.0004127074],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004601546,"about_ca_system_score_gemma":0.0002403459,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001868203,"about_ca_topic_score_gemma":0.001162751,"domain_scores_codex":[0.999922,0.00001321276,0.000005691677,0.00001794617,0.00002475112,0.00001625793],"domain_scores_gemma":[0.9998801,0.00002015471,0.00002346701,0.00001132359,0.00002160211,0.00004338666],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001392509,0.00006430544,0.0008045086,0.00005496827,0.000009207915,0.0001194805,0.00005260001,0.0003542524,0.9956936,0.0003560248,0.00009813321,0.002253666],"study_design_scores_gemma":[0.00004192178,0.0003376758,0.02399801,0.000026959,0.00003478926,0.001235098,0.0001894215,0.005897109,0.9495798,0.0004561026,0.0181741,0.00002904086],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952868,0.001316083,0.002061209,0.0001109671,0.00001140255,0.00001288154,0.0004919281,0.00002460047,0.0006840159],"genre_scores_gemma":[0.9836638,0.001023486,0.006234088,0.00008696163,0.00001580047,0.000023321,0.00514343,0.00005222106,0.003756888],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001868203,"threshold_uncertainty_score":0.003714621,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007493006262069122,"score_gpt":0.197600805467882,"score_spread":0.1901077992058129,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}