{"id":"W1972592088","doi":"10.1021/bi901620v","title":"Structural and Functional Characterization of the Monomeric U-Box Domain from E4B","year":2009,"lang":"en","type":"article","venue":"Biochemistry","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Institute of Environmental Health Sciences; National Institute of General Medical Sciences; National Cancer Institute","keywords":"Monomer; Ubiquitin; Ubiquitin-Protein Ligases; Domain (mathematical analysis); Protein structure; Escherichia coli; Function (biology); Chemistry; Ubiquitin-conjugating enzyme; Biochemistry; Sequence alignment; Sequence (biology); Stereochemistry; Biology; Peptide sequence; Ubiquitin ligase; Cell biology; Gene; Polymer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000339902,0.00009042901,0.00007261157,0.000006188091,0.00005314694,0.00001032496,0.00008677618,0.0001013899,0.00003957898],"category_scores_gemma":[0.00001740241,0.00007088299,0.00004478795,0.00004279754,0.00006258314,0.000002205988,0.00004506193,0.00004925243,8.791868e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005652419,"about_ca_system_score_gemma":0.00003296166,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003441334,"about_ca_topic_score_gemma":3.425859e-7,"domain_scores_codex":[0.9995214,0.00001609106,0.0001130129,0.0001849997,0.00007489901,0.00008956077],"domain_scores_gemma":[0.9996463,0.000003077474,0.00008120435,0.0002062787,0.00002774028,0.00003539143],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003593591,0.000008460818,0.002598904,0.000006372649,0.00001035039,1.144978e-7,0.00001632544,5.263127e-7,0.9958965,0.00002175659,0.00005426396,0.001350543],"study_design_scores_gemma":[0.0001941689,0.00002764377,0.1152149,0.000007927226,0.000005409322,0.000005355436,0.00001427545,0.00001123214,0.8836221,0.0002148742,0.0006043912,0.000077674],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987387,0.0002253539,0.0001258254,0.0001768652,0.00007233604,0.00006913692,0.00009442472,0.000005562338,0.000491773],"genre_scores_gemma":[0.9987971,0.0000197147,0.0001993256,0.0001628118,0.0002505741,0.000003896763,0.0003205998,0.000005337758,0.0002406708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.112616,"threshold_uncertainty_score":0.2890525,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007493006262069122,"score_gpt":0.197600805467882,"score_spread":0.1901077992058129,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}