{"id":"W1972599183","doi":"10.1371/journal.pgen.1000067","title":"A Genetic Screen for Dihydropyridine (DHP)-Resistant Worms Reveals New Residues Required for DHP-Blockage of Mammalian Calcium Channels","year":2008,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; National Institutes of Health; National Center for Research Resources; Heart and Stroke Foundation of Canada","keywords":"Biology; Depolarization; Voltage-dependent calcium channel; Mutant; Calcium channel; Caenorhabditis elegans; Missense mutation; Ion channel; Mutation; Protein subunit; Dihydropyridine; Biophysics; N-type calcium channel; Calcium; Genetics; Biochemistry; T-type calcium channel; Gene; Chemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001036984,0.0004983119,0.0002677352,0.0003805903,0.0001828589,0.000172917,0.0002996532,0.0004110807,0.001054107],"category_scores_gemma":[0.0002655476,0.0001738058,0.00040354,0.0002401517,0.0002036752,0.0000991429,0.0002026155,0.000400079,0.0002657353],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000203803,"about_ca_system_score_gemma":0.0001727474,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009537502,"about_ca_topic_score_gemma":0.002144926,"domain_scores_codex":[0.9998679,0.00001581318,0.00001913097,0.00003405663,0.00004221892,0.00002083372],"domain_scores_gemma":[0.9997368,0.00007201616,0.00009758246,0.00002294109,0.00002260003,0.00004795645],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005680066,0.00003289073,0.0006027693,0.0000263587,0.00001561548,0.0001929951,0.00001400298,0.00007427607,0.9978293,0.00004043577,0.00002725598,0.001087339],"study_design_scores_gemma":[0.00008906702,0.00114592,0.1051025,0.000042354,0.0002070993,0.003856516,0.0001269609,0.003889768,0.8809421,0.00008071844,0.004478069,0.00003894889],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955461,0.0002744534,0.002324511,0.00004493893,0.0000174756,0.00009639237,0.0009613174,0.00008538686,0.0006494629],"genre_scores_gemma":[0.9899955,0.0004456653,0.005882334,0.00008577833,0.00001075679,0.00005940461,0.00197771,0.00006743293,0.001475435],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001054107,"threshold_uncertainty_score":0.00352633,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05401710562929416,"score_gpt":0.273322982249453,"score_spread":0.2193058766201589,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}