{"id":"W1972599183","doi":"10.1371/journal.pgen.1000067","title":"A Genetic Screen for Dihydropyridine (DHP)-Resistant Worms Reveals New Residues Required for DHP-Blockage of Mammalian Calcium Channels","year":2008,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; National Institutes of Health; National Center for Research Resources; Heart and Stroke Foundation of Canada","keywords":"Biology; Depolarization; Voltage-dependent calcium channel; Mutant; Calcium channel; Caenorhabditis elegans; Missense mutation; Ion channel; Mutation; Protein subunit; Dihydropyridine; Biophysics; N-type calcium channel; Calcium; Genetics; Biochemistry; T-type calcium channel; Gene; Chemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000144218,0.0002722384,0.0003384262,0.0001068683,0.0001756479,0.00001738138,0.0002439952,0.0002748215,0.00002383397],"category_scores_gemma":[0.0001512837,0.0002631301,0.0002346293,0.0001470984,0.0001117021,0.000005575865,0.00007262309,0.0000563699,0.000004452315],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002527985,"about_ca_system_score_gemma":0.0001539432,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001680688,"about_ca_topic_score_gemma":0.00002921876,"domain_scores_codex":[0.9982361,0.00004205094,0.0005554919,0.0004934007,0.0002487834,0.0004241384],"domain_scores_gemma":[0.9987003,0.00003089841,0.0002171543,0.0005090294,0.0003423288,0.0002003023],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00095908,0.0001280141,0.000502539,0.0001391129,0.0001252783,0.000002141779,0.000139189,0.001966547,0.9772269,0.00007485177,0.01826545,0.0004708575],"study_design_scores_gemma":[0.001959584,0.00144969,0.001061066,0.00004637672,0.0001015632,0.00001271982,0.00003824217,0.006313835,0.9680697,0.0007762755,0.01979166,0.0003792401],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9427355,0.001237485,0.05336685,0.0005576877,0.0004155977,0.001335212,0.0002188395,0.00003093619,0.0001019172],"genre_scores_gemma":[0.9804664,0.0002157683,0.009583975,0.0002164504,0.002012308,0.0001149625,0.0004318752,0.00008258668,0.006875668],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04378288,"threshold_uncertainty_score":0.9999821,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05401710562929416,"score_gpt":0.273322982249453,"score_spread":0.2193058766201589,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}