{"id":"W1972610823","doi":"10.1073/pnas.1417594112","title":"Human RECQ1 helicase-driven DNA unwinding, annealing, and branch migration: Insights from DNA complex structures","year":2015,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Interreg; National Institutes of Health; Cancer Research UK; Ontario Ministry of Economic Development and Innovation; Ministero dello Sviluppo Economico; National Institute of General Medical Sciences; Diamond Light Source; Genome Canada; Francis Crick Institute; Wellcome Trust; Saint Louis University; GlaxoSmithKline; Pfizer; Eli Lilly and Company","keywords":"Holliday junction; Helicase; Branch migration; DNA; RecQ helicase; Biology; Human genome; RNA Helicase A; Genetics; Biophysics; DNA repair; Computational biology; Genome; Gene; RNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008883789,0.0002774161,0.0001772667,0.0002191729,0.0002311851,0.0003134488,0.0002604406,0.0003184732,0.0005725918],"category_scores_gemma":[0.0001547386,0.0002170062,0.000157175,0.0002057091,0.0001716025,0.0004939547,0.0001216626,0.0003837823,0.0002070736],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004810446,"about_ca_system_score_gemma":0.0001429681,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008280133,"about_ca_topic_score_gemma":0.001446044,"domain_scores_codex":[0.9999723,0.00000431671,0.000001637821,0.00001049483,0.000006509031,0.000004621271],"domain_scores_gemma":[0.9999593,0.000009922063,0.000008837489,0.000004655333,0.000005433052,0.00001173252],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001641287,0.00005947099,0.002452251,0.0002191128,0.00001775163,0.0003394944,0.0002128917,0.00395465,0.9807616,0.002264189,0.0004104907,0.009143916],"study_design_scores_gemma":[0.0000785037,0.0003441524,0.04110244,0.00005199875,0.00006302622,0.001998412,0.0003922721,0.0602093,0.8672367,0.005572321,0.02289163,0.00005928201],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856026,0.004362346,0.008279019,0.0002909483,0.000009154286,0.00001471531,0.0002381491,0.00007249144,0.001130499],"genre_scores_gemma":[0.9853891,0.003374367,0.00909394,0.00006799238,0.000009412753,0.00001336382,0.0008073983,0.00001782063,0.001226669],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008280133,"threshold_uncertainty_score":0.00349021,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05635267982205321,"score_gpt":0.3136524314474183,"score_spread":0.2572997516253651,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}