{"id":"W1972610823","doi":"10.1073/pnas.1417594112","title":"Human RECQ1 helicase-driven DNA unwinding, annealing, and branch migration: Insights from DNA complex structures","year":2015,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Interreg; National Institutes of Health; Cancer Research UK; Ontario Ministry of Economic Development and Innovation; Ministero dello Sviluppo Economico; National Institute of General Medical Sciences; Diamond Light Source; Genome Canada; Francis Crick Institute; Wellcome Trust; Saint Louis University; GlaxoSmithKline; Pfizer; Eli Lilly and Company","keywords":"Holliday junction; Helicase; Branch migration; DNA; RecQ helicase; Biology; Human genome; RNA Helicase A; Genetics; Biophysics; DNA repair; Computational biology; Genome; Gene; RNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000301263,0.000101641,0.0001245356,0.00007040981,0.0001704419,0.0000309928,0.0004726221,0.0001181105,0.000005363061],"category_scores_gemma":[0.0002086282,0.00007307196,0.0000452707,0.0001930706,0.0004609405,0.00002959136,0.0001819692,0.00007464889,4.060502e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001290402,"about_ca_system_score_gemma":0.00003106913,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001579263,"about_ca_topic_score_gemma":0.000002352152,"domain_scores_codex":[0.9987653,0.0000104081,0.0002277476,0.0002955575,0.0005950664,0.000105905],"domain_scores_gemma":[0.9993847,0.00001271149,0.0002916806,0.0000146032,0.0002363542,0.00005996287],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000009359233,0.00001199582,0.002365642,0.00001050087,0.00001558408,5.470361e-9,0.0002050778,0.00002737002,0.9874577,0.008095943,0.001722876,0.00007797941],"study_design_scores_gemma":[0.0002372329,0.0001130953,0.02788558,0.00002568378,0.00001004899,0.000005977813,0.0001855053,0.0003216378,0.9134713,0.05643085,0.001219173,0.0000939446],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975675,0.0002220995,0.000001907036,0.0006362717,0.00002162637,0.0001235791,0.00002583965,0.000007944971,0.001393279],"genre_scores_gemma":[0.9973575,0.00001217313,0.002101742,0.0002702881,0.0001737659,0.000004766641,0.000003187857,0.000005214839,0.00007139234],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07398639,"threshold_uncertainty_score":0.2979788,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05635267982205321,"score_gpt":0.3136524314474183,"score_spread":0.2572997516253651,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}