{"id":"W1972617547","doi":"10.1016/j.vaccine.2008.12.044","title":"Reduced oligomeric and vascular amyloid-β following immunization of TgCRND8 mice with an Alzheimer's DNA vaccine","year":2009,"lang":"en","type":"article","venue":"Vaccine","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Immunogen; Immunization; Immune system; DNA vaccination; Immunology; Antibody; Amyloid (mycology); Biology; Active immunization; Alzheimer's disease; Amyloid precursor protein; Epitope; Medicine; Disease; Pathology; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002725516,0.0007122091,0.0006686039,0.0005575584,0.0002014952,0.0004562976,0.0004337847,0.001016388,0.001528343],"category_scores_gemma":[0.0003338251,0.0003206344,0.0004402819,0.0001968035,0.000475053,0.0004798892,0.0001983152,0.00211428,0.0004967161],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003963824,"about_ca_system_score_gemma":0.0003098282,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001107651,"about_ca_topic_score_gemma":0.0008838115,"domain_scores_codex":[0.9996587,0.00003930779,0.00003350123,0.00007247385,0.00006464001,0.0001314608],"domain_scores_gemma":[0.9995757,0.00006692272,0.0001392063,0.0000493929,0.00006541194,0.0001033667],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000816092,0.0002128394,0.0001132185,0.00003308481,0.00001609146,0.00006583497,0.00002871362,0.0001308815,0.9976305,0.0001267944,0.00006155419,0.0007644226],"study_design_scores_gemma":[0.000206609,0.001838572,0.002325663,0.00001386397,0.00008172921,0.0003755634,0.00005137224,0.00171967,0.9915604,0.00020852,0.001604949,0.00001313278],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996878,0.0004053988,0.001324179,0.0001116009,0.00007734228,0.00003560815,0.0003039461,0.00008788419,0.0007760247],"genre_scores_gemma":[0.9948123,0.0003329168,0.0009283104,0.0000980459,0.00002425832,0.00004546839,0.0005908094,0.00004947545,0.003118324],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001528343,"threshold_uncertainty_score":0.005112827,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01576772234632906,"score_gpt":0.2880578859250406,"score_spread":0.2722901635787115,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}