{"id":"W1972634563","doi":"10.1006/jmbi.2000.4190","title":"Differential stabilization of two hydrophobic cores in the transition state of the villin 14T folding reaction 1 1Edited by A. Fersht","year":2000,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health","keywords":"Chemistry; Contact order; Protein folding; Hydrophobic effect; Lattice protein; Folding (DSP implementation); Phi value analysis; Villin; Crystallography; Downhill folding; Chemical physics; Folding funnel; Transition state; Native state; Organic chemistry; Biochemistry; Catalysis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001594813,0.0002155314,0.0002489763,0.0001514671,0.000620013,0.0004580297,0.000178231,0.000262929,0.001993471],"category_scores_gemma":[0.0003578371,0.0001702215,0.0001743399,0.0001333134,0.0006156634,0.0002925709,0.0003948633,0.0005659264,0.0002828265],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005765752,"about_ca_system_score_gemma":0.0002247376,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001091298,"about_ca_topic_score_gemma":0.001017493,"domain_scores_codex":[0.9999166,0.00001359668,0.00000235134,0.00002198994,0.00001386576,0.00003166068],"domain_scores_gemma":[0.9998885,0.00003543971,0.00002550441,0.000006359602,0.00001166473,0.0000324767],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007351265,0.00005096228,0.000935921,0.0000777417,0.00001694693,0.000435868,0.0001336039,0.001741653,0.9874514,0.004031974,0.0003594454,0.004029374],"study_design_scores_gemma":[0.0001031348,0.0006001103,0.01166013,0.00002102003,0.0000222241,0.000464524,0.0001579547,0.01993388,0.9619954,0.002882218,0.002111404,0.00004801495],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971641,0.0003726552,0.001117077,0.00009152131,0.00002578136,0.000005768674,0.00003060748,0.00004210283,0.001150313],"genre_scores_gemma":[0.9990683,0.00008160177,0.000282695,0.00001686037,0.000005315621,0.000003509754,0.00003407122,0.00001122866,0.0004963593],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001993471,"threshold_uncertainty_score":0.006668866,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003541496555602112,"score_gpt":0.2383194806524892,"score_spread":0.2347779840968871,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}