{"id":"W1972640898","doi":"10.1111/j.1600-6143.2004.00384.x","title":"Multiple Combination Therapies Involving Blockade of ICOS/B7RP-1 Costimulation Facilitate Long-Term Islet Allograft Survival","year":2004,"lang":"en","type":"article","venue":"American Journal of Transplantation","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; U.S. Public Health Service; Fondation pour la Recherche Médicale; NIH Clinical Center; National Institutes of Health; University of Alberta; Bristol-Myers Squibb","keywords":"Islet; Medicine; Blockade; Monoclonal antibody; Transplantation; Major histocompatibility complex; Abatacept; Immunology; CD40; T cell; Cancer research; Cytotoxic T cell; Immune system; Receptor; Antibody; Biology; Internal medicine; Insulin; In vitro; Rituximab","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000292255,0.0008460174,0.001028478,0.000586372,0.0001774992,0.0004698161,0.0003804231,0.0003304673,0.001091316],"category_scores_gemma":[0.0001082039,0.0001317636,0.0003712658,0.0002766399,0.0002589389,0.0004100892,0.0002650261,0.001450103,0.000365609],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002049029,"about_ca_system_score_gemma":0.000257113,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001214176,"about_ca_topic_score_gemma":0.0006209163,"domain_scores_codex":[0.9997094,0.00004463052,0.00002767921,0.00003992452,0.0000885076,0.00008983857],"domain_scores_gemma":[0.9998274,0.00002819975,0.00004398453,0.000023882,0.00001355912,0.00006292405],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001503984,0.00145414,0.0007273355,0.0002243779,0.0001054212,0.0001423773,0.00003713623,0.0008954109,0.9456176,0.0003832211,0.0004748177,0.04843414],"study_design_scores_gemma":[0.0003893914,0.01588849,0.006732615,0.00003113879,0.0003761857,0.0008887636,0.00005741015,0.00241342,0.9638041,0.0002145182,0.009180628,0.00002327519],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9853431,0.007035568,0.004382147,0.0001715639,0.0001683943,0.0001259816,0.0001238925,0.000202607,0.002446587],"genre_scores_gemma":[0.9909737,0.002874396,0.003927559,0.00009069969,0.0001248893,0.0001212899,0.0002247823,0.0000242629,0.001638426],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001091316,"threshold_uncertainty_score":0.003650784,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02203842001590292,"score_gpt":0.2649351855827122,"score_spread":0.2428967655668093,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}