{"id":"W1972669737","doi":"10.1074/jbc.m600752200","title":"The Structural Integrity of Anion Binding Exosite I of Thrombin Is Required and Sufficient for Timely Cleavage and Activation of Factor V and Factor VIII","year":2006,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Blood Coagulation and Thrombosis Mechanisms","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Heart, Lung, and Blood Institute","keywords":"Cleavage (geology); Thrombin; Factor (programming language); Structural integrity; Chemistry; Computer science; Materials science; Engineering; Biology; Immunology; Structural engineering; Platelet","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001783104,0.0002518808,0.0002208433,0.00009396239,0.00009682478,0.0005680597,0.0001695543,0.0002548647,0.001176156],"category_scores_gemma":[0.0004247566,0.0001969915,0.0001899938,0.0000722644,0.0002246356,0.0002662844,0.0002019283,0.0004368665,0.0004200826],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003362093,"about_ca_system_score_gemma":0.0002605931,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002800486,"about_ca_topic_score_gemma":0.0003175512,"domain_scores_codex":[0.999772,0.00004938216,0.00003216443,0.00004430947,0.0000530236,0.0000491129],"domain_scores_gemma":[0.9996065,0.00007651767,0.0001453445,0.00004654954,0.00003494208,0.00009008498],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000842519,0.0000123997,0.0002529818,0.00001246491,0.000002625101,0.00003413678,0.000007612857,0.00003513887,0.9989079,0.0000627644,0.00001036647,0.0005773075],"study_design_scores_gemma":[0.00001627819,0.0002277888,0.01063514,0.000006177018,0.00000941731,0.0005495589,0.00002907982,0.0005447121,0.9862404,0.00004277967,0.001694752,0.00000398086],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970493,0.0005752333,0.001359213,0.00004191283,0.00001231524,0.00001289279,0.0001058728,0.00002165527,0.0008214869],"genre_scores_gemma":[0.9971911,0.0001656786,0.001193554,0.00002570024,0.000007602622,0.00001463805,0.0005305219,0.00001431576,0.0008569795],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001176156,"threshold_uncertainty_score":0.003934622,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05069770002061841,"score_gpt":0.2983399130465624,"score_spread":0.247642213025944,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}