{"id":"W1972688821","doi":"10.1038/nature10988","title":"Inositol-1,4,5-trisphosphate receptor regulates hepatic gluconeogenesis in fasting and diabetes","year":2012,"lang":"en","type":"article","venue":"Nature","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":210,"is_retracted":false,"has_abstract":false,"ca_institutions":"Children's Hospital of Eastern Ontario; University of Ottawa","funders":"National Institute of General Medical Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute","keywords":"Endocrinology; Internal medicine; Calcineurin; Dephosphorylation; Glucagon; Inositol; Chemistry; Downregulation and upregulation; Gluconeogenesis; Phosphatase; Biology; Phosphorylation; Insulin; Cell biology; Receptor; Biochemistry; Medicine; Metabolism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001673602,0.0001837576,0.0002669178,0.000316312,0.0002137102,0.0004262806,0.0001591901,0.0002107761,0.0008742036],"category_scores_gemma":[0.0001251833,0.0002147736,0.0002239504,0.0001940547,0.0002783707,0.00023434,0.0001872169,0.0003763865,0.0001689376],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005867651,"about_ca_system_score_gemma":0.0002425763,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002324706,"about_ca_topic_score_gemma":0.003919816,"domain_scores_codex":[0.999951,0.00001052476,0.000003219355,0.000007932166,0.000008621434,0.00001868912],"domain_scores_gemma":[0.9999274,0.00001075365,0.00001274139,0.000008923676,0.00001021205,0.00002992396],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009031473,0.00009367406,0.009391343,0.00007343558,0.00008706364,0.0007771584,0.0001037767,0.0003966854,0.9591792,0.001537332,0.001497067,0.01783188],"study_design_scores_gemma":[0.0008096664,0.001204044,0.6213248,0.00007185859,0.0004816765,0.002479012,0.0009231697,0.003988521,0.351919,0.004999044,0.01168691,0.0001123562],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864677,0.008153464,0.001212134,0.0007141383,0.00009746587,0.000009200042,0.0002681093,0.00009201494,0.002985609],"genre_scores_gemma":[0.9942186,0.002230063,0.0004822667,0.0001480884,0.00003532033,0.000009645651,0.0001949229,0.00002152073,0.002659641],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002324706,"threshold_uncertainty_score":0.00462234,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004095915536234763,"score_gpt":0.2264839455526476,"score_spread":0.2223880300164128,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}