{"id":"W1972717729","doi":"10.1038/nchembio.1119","title":"Evolving superkines for selectivity","year":2012,"lang":"en","type":"letter","venue":"Nature Chemical Biology","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Computational biology; Protein expression; Chemistry; Selectivity; Differential (mechanical device); Cell biology; Combinatorial chemistry; Biology; Biochemistry; Gene; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["research_integrity"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.0001424516,0.0003398408,0.0007138845,0.0001160382,0.00006019263,0.00001017857,0.0002305605,0.004864496,0.0004111514],"category_scores_gemma":[0.0009653742,0.0002338397,0.0003655638,0.0001284197,0.0002231595,0.00002637293,0.0001252437,0.005720917,0.00005588602],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000101723,"about_ca_system_score_gemma":0.0001155018,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001452839,"about_ca_topic_score_gemma":6.386119e-7,"domain_scores_codex":[0.9981227,0.00005920081,0.0002228495,0.000546704,0.0002046421,0.000843885],"domain_scores_gemma":[0.9981946,0.00111732,0.00006236426,0.0002555748,0.0002331367,0.000137035],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001724079,0.00004008125,0.001245175,0.0004739759,0.0001122813,0.00002861088,0.000006268798,9.408271e-10,0.2394604,0.0001113362,0.7564515,0.001897981],"study_design_scores_gemma":[0.0003632035,0.0001150831,0.0001053423,0.00004851693,0.00008248437,0.0002036937,5.040104e-7,0.000007393534,0.1322685,0.0006907363,0.8658916,0.000222961],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.02112381,0.01230105,0.00002674896,0.9585298,0.0009450879,0.0008565346,0.0004337897,0.000109627,0.005673539],"genre_scores_gemma":[0.1108667,0.0002324087,0.001848253,0.8333201,0.04042695,0.000163003,0.005405817,0.00009030342,0.00764651],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.1252097,"threshold_uncertainty_score":0.9965729,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02625869816184757,"score_gpt":0.3499388081866148,"score_spread":0.3236801100247672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}