{"id":"W1972717729","doi":"10.1038/nchembio.1119","title":"Evolving superkines for selectivity","year":2012,"lang":"en","type":"letter","venue":"Nature Chemical Biology","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Computational biology; Protein expression; Chemistry; Selectivity; Differential (mechanical device); Cell biology; Combinatorial chemistry; Biology; Biochemistry; Gene; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002975557,0.0005428898,0.0008793083,0.0003834334,0.00268235,0.003331895,0.001409596,0.01754601,0.007092979],"category_scores_gemma":[0.007378366,0.0005112209,0.0005682803,0.0002449111,0.005451332,0.005045646,0.002428575,0.0196627,0.003497647],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003586609,"about_ca_system_score_gemma":0.001694372,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009506054,"about_ca_topic_score_gemma":0.001974996,"domain_scores_codex":[0.9979971,0.0003539212,0.00007922394,0.0002734667,0.0008716309,0.0004247192],"domain_scores_gemma":[0.9977701,0.001172711,0.0001221682,0.0002248653,0.0003559527,0.0003542263],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003462155,0.00008698744,0.000363221,0.0001556291,0.00003769814,0.001837709,0.0002806709,0.0004338311,0.009103981,0.3120968,0.6126615,0.06259573],"study_design_scores_gemma":[0.0002289735,0.0001930822,0.0001449687,0.00007429102,0.00002507653,0.001099065,0.0001941698,0.001646764,0.006916897,0.2007721,0.7886579,0.00004673592],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.00762863,0.01362462,0.008251092,0.9071198,0.021062,0.00004745174,0.00008708389,0.0002592239,0.04192014],"genre_scores_gemma":[0.195181,0.008592902,0.007933904,0.7020199,0.01908016,0.0002725286,0.0000854483,0.000163851,0.06667035],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.01754601,"threshold_uncertainty_score":0.02602279,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02625869816184757,"score_gpt":0.3499388081866148,"score_spread":0.3236801100247672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}