{"id":"W1972727429","doi":"10.1016/j.leukres.2011.06.035","title":"Induction of apoptosis in pediatric acute lymphoblastic leukemia (ALL) cells by the therapeutic opioid methadone and effective synergy with Bcl-2 inhibition","year":2011,"lang":"en","type":"article","venue":"Leukemia Research","topic":"Cancer, Stress, Anesthesia, and Immune Response","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary; Alberta Children's Hospital","funders":"","keywords":"Methadone; Apoptosis; Medicine; Leukemia; Pharmacology; Programmed cell death; Opioid; Cytotoxicity; Population; Cancer research; Oncology; Immunology; Internal medicine; Biology; Receptor; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001231821,0.0002232024,0.000420412,0.0005341972,0.0001270097,0.00002585808,0.0001485957,0.0002087317,0.00003643538],"category_scores_gemma":[0.00009076642,0.0001467184,0.00006856745,0.001068448,0.0004971165,0.0001622351,0.00007563846,0.0006813417,0.00001247396],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0014309,"about_ca_system_score_gemma":0.0009207553,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003880012,"about_ca_topic_score_gemma":0.00007767048,"domain_scores_codex":[0.9973447,0.0006823697,0.0003349624,0.0004213168,0.000700062,0.0005165431],"domain_scores_gemma":[0.9983512,0.0007469885,0.0001222831,0.0004239812,0.000231158,0.0001243821],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.03066909,0.0007734024,0.01369561,0.001622959,0.0008090272,0.0001470648,0.01428107,0.00005870696,0.8369305,0.0003178635,0.002977032,0.09771772],"study_design_scores_gemma":[0.008899517,0.0044285,0.1321581,0.0004936664,0.0005410054,0.0003102899,0.002329288,0.0004415537,0.8485836,0.000288013,0.001121401,0.0004050396],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955419,0.002551511,0.00007792918,0.0001426946,0.00006594851,0.0009999528,0.000007452134,0.00002480128,0.0005878229],"genre_scores_gemma":[0.9928781,0.006007969,0.00007144617,0.00007259175,0.0001559312,0.0002743089,0.00001438564,0.00004326735,0.0004820344],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1184625,"threshold_uncertainty_score":0.5983002,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02765918192295676,"score_gpt":0.2904673109659687,"score_spread":0.262808129043012,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}