{"id":"W1972728563","doi":"10.1038/cgt.2013.19","title":"Ultrasound-targeted HSVtk and Timp3 gene delivery for synergistically enhanced antitumor effects in hepatoma","year":2013,"lang":"en","type":"article","venue":"Cancer Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research; National Natural Science Foundation of China","keywords":"Genetic enhancement; Suicide gene; Cancer research; Transfection; Gene delivery; Thymidine kinase; Medicine; Viability assay; Cell culture; Gene; Biology; Immunology; Herpes simplex virus; Virus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002083031,0.0002813019,0.0002978959,0.00008905376,0.00009659299,0.00005457414,0.0002692666,0.0001743361,0.0001190849],"category_scores_gemma":[0.00005815503,0.0002605054,0.0000934091,0.0001576793,0.0001451523,0.0000104413,0.00004691975,0.0001116861,0.00001439634],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005389893,"about_ca_system_score_gemma":0.000200511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001628331,"about_ca_topic_score_gemma":0.0002359487,"domain_scores_codex":[0.9982959,0.0001194482,0.0002545998,0.0005957578,0.0001671577,0.0005671294],"domain_scores_gemma":[0.999058,0.00008675348,0.00006769121,0.0004269264,0.0001897886,0.0001708522],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001838985,0.00007723346,0.001456379,0.00003356077,0.0001214157,0.000003471999,0.00004872288,0.0000936096,0.9655263,0.00000471457,0.0006257059,0.03016993],"study_design_scores_gemma":[0.002710833,0.002037503,0.009156602,0.00001830942,0.000008512018,0.00000706276,0.00001101064,0.0002720314,0.9845124,0.0001886719,0.0007441045,0.0003329842],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9772421,0.01881706,0.00230959,0.0001157091,0.0001569382,0.001250662,0.00005294504,0.0000239795,0.00003098841],"genre_scores_gemma":[0.9811204,0.0147087,0.001341337,0.0009667885,0.000328457,0.001152418,0.0001133282,0.0000712169,0.0001973584],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02983694,"threshold_uncertainty_score":0.9999847,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01123149494650877,"score_gpt":0.283599526336274,"score_spread":0.2723680313897652,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}