{"id":"W1972735052","doi":"10.1523/jneurosci.1589-10.2010","title":"Phosphorylation of Huntingtin at Ser<sup>421</sup>in YAC128 Neurons Is Associated with Protection of YAC128 Neurons from NMDA-Mediated Excitotoxicity and Is Modulated by PP1 and PP2A","year":2010,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research; Killam Trusts; Michael Smith Health Research BC","keywords":"Excitotoxicity; Huntingtin; NMDA receptor; Striatum; Phosphorylation; Medium spiny neuron; Chemistry; Genetically modified mouse; Quinolinic acid; Neuroscience; Cell biology; Transgene; Neurodegeneration; Biology; Internal medicine; Dopamine; Biochemistry; Receptor; Mutant; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003659814,0.0003270941,0.0005157869,0.0003072266,0.0002253154,0.00008335487,0.0004187516,0.0001283079,0.00002792539],"category_scores_gemma":[0.002675217,0.0002863824,0.00008508327,0.001103259,0.0008995472,0.0005282543,0.0001755383,0.0006412358,9.20774e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003317873,"about_ca_system_score_gemma":0.0001420036,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008526089,"about_ca_topic_score_gemma":0.00003715185,"domain_scores_codex":[0.9965893,0.0004105448,0.0008578581,0.0007654253,0.0009733254,0.0004035216],"domain_scores_gemma":[0.9972937,0.0004567364,0.001354769,0.0003341671,0.0002871799,0.000273497],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001733871,0.000303932,0.03348378,0.00001551256,0.00000349094,0.00001951536,0.0004745651,0.0005455655,0.9646738,0.000001997748,0.0001051341,0.0001993171],"study_design_scores_gemma":[0.0009558397,0.0006187042,0.2819862,0.00005006404,0.0000200111,0.00004470584,0.00002237993,0.03376666,0.6822844,0.00004228965,0.00004512767,0.0001636838],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982957,0.00003385677,0.0001211753,0.0004913837,0.0002367632,0.0004911768,0.0002919311,0.00002126569,0.0000168017],"genre_scores_gemma":[0.999015,0.00009645501,0.00006349693,0.0006889154,0.0000267907,0.000007311431,0.000002156616,0.00003571359,0.00006421221],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2823895,"threshold_uncertainty_score":0.9999588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01854075481794149,"score_gpt":0.2336305941227052,"score_spread":0.2150898393047637,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}