{"id":"W1972752819","doi":"10.1177/009127002401102803","title":"Pharmacokinetics of GW433908, a Prodrug of Amprenavir, in Healthy Male Volunteers","year":2002,"lang":"en","type":"article","venue":"The Journal of Clinical Pharmacology","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Smiths Detection (Canada)","funders":"","keywords":"Amprenavir; Pharmacokinetics; Bioequivalence; Pharmacology; Prodrug; Bioavailability; Crossover study; Medicine; Chemistry; Protease; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006447143,0.001084641,0.001371088,0.0002687374,0.000534924,0.0003741721,0.0002163699,0.00092983,0.002163369],"category_scores_gemma":[0.001140642,0.000805177,0.0007238404,0.0002354485,0.0006662215,0.0006652786,0.0002594621,0.001092394,0.0007433851],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002239081,"about_ca_system_score_gemma":0.0002851444,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000834002,"about_ca_topic_score_gemma":0.0008629987,"domain_scores_codex":[0.9995704,0.0001436964,0.00002463806,0.0001305723,0.00006853919,0.00006213094],"domain_scores_gemma":[0.9995757,0.00009639032,0.00008107828,0.00005690306,0.00005379326,0.0001363021],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4925779,0.03325516,0.03252587,0.0006749794,0.001128991,0.0006323922,0.001604811,0.0009091597,0.3428293,0.0002557097,0.002590393,0.09101541],"study_design_scores_gemma":[0.06386673,0.6482898,0.2314558,0.00002752681,0.00154865,0.001220453,0.0003532456,0.003102695,0.04432385,0.0003782012,0.005252689,0.0001803408],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974808,0.0005807676,0.0005606574,0.00005156879,0.0000571339,0.0003495714,0.0003929464,0.00005506783,0.0004714716],"genre_scores_gemma":[0.9959188,0.0003474901,0.0009911413,0.0002559335,0.00008192484,0.0003910848,0.0004750614,0.00002089622,0.001517596],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002163369,"threshold_uncertainty_score":0.007237256,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08639558196707112,"score_gpt":0.4306749514898969,"score_spread":0.3442793695228258,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}