{"id":"W1972757865","doi":"10.1016/j.chemosphere.2009.09.044","title":"Reproductive performance in East Greenland polar bears (Ursus maritimus) may be affected by organohalogen contaminants as shown by physiologically-based pharmacokinetic (PBPK) modelling","year":2009,"lang":"en","type":"article","venue":"Chemosphere","topic":"Per- and polyfluoroalkyl substances research","field":"Environmental Science","cited_by":72,"is_retracted":false,"has_abstract":false,"ca_institutions":"Carleton University; Environment and Climate Change Canada","funders":"","keywords":"Ursus maritimus; Dieldrin; Physiologically based pharmacokinetic modelling; Polybrominated diphenyl ethers; Reproduction; Biology; Zoology; Pharmacokinetics; Environmental chemistry; Pesticide; Ecology; Chemistry; Pollutant; Pharmacology; Arctic","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000266581,0.0002004564,0.0001956025,0.0001942513,0.0002811133,0.0003262939,0.0001670202,0.0003049198,0.0006270033],"category_scores_gemma":[0.0004124516,0.0001677885,0.0001371107,0.00009510117,0.000368545,0.0001769812,0.0001641121,0.0001963091,0.0001540038],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006319598,"about_ca_system_score_gemma":0.0003288203,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01656101,"about_ca_topic_score_gemma":0.03440312,"domain_scores_codex":[0.9999403,0.00001964587,0.000001929452,0.00001796199,0.000007113309,0.00001308944],"domain_scores_gemma":[0.999818,0.00005773526,0.00005802765,0.00001809838,0.00001463527,0.00003340804],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.001759537,0.0004144069,0.8417598,0.00005156902,0.0002335827,0.0005668212,0.0007392421,0.004063998,0.1381822,0.000334815,0.0005478602,0.01134611],"study_design_scores_gemma":[0.000009879253,0.0004199025,0.9941022,0.000002671065,0.00002612926,0.0001291756,0.0001555373,0.001585592,0.003124534,0.00009884639,0.000340322,0.000005241515],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996037,0.0000658172,0.00006732404,0.00001556966,9.778687e-7,0.000002447834,0.00006253218,0.000003115025,0.0001785516],"genre_scores_gemma":[0.9988422,0.00009183581,0.0001365654,0.00001908517,0.000001375182,0.000007913755,0.0001431714,0.000003778242,0.0007540255],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01656101,"threshold_uncertainty_score":0.03292918,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01581127205069572,"score_gpt":0.2504404663750469,"score_spread":0.2346291943243512,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}