{"id":"W1972759524","doi":"10.1016/j.yexcr.2007.05.019","title":"A mutation of keratin 18 within the coil 1A consensus motif causes widespread keratin aggregation but cell type-restricted lethality in mice","year":2007,"lang":"en","type":"article","venue":"Experimental Cell Research","topic":"Skin and Cellular Biology Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; Deutsche Forschungsgemeinschaft","keywords":"Biology; Keratin; Mutant; Endogeny; Mutation; Allele; Wild type; Embryonic stem cell; Cell biology; Keratin 8; Keratin 14; Cell type; Keratin 6A; Genetics; Cell; Molecular biology; Intermediate filament; Gene; Cytoskeleton; Transgene; Genetically modified mouse; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002794339,0.001322318,0.0004899835,0.001547051,0.0004238545,0.0003288923,0.000508335,0.0009145914,0.002932805],"category_scores_gemma":[0.0002784923,0.0005651491,0.0006658575,0.0003832986,0.0007569178,0.0002654104,0.000609044,0.001219124,0.001036088],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004052465,"about_ca_system_score_gemma":0.0003215616,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008454972,"about_ca_topic_score_gemma":0.001300658,"domain_scores_codex":[0.9995764,0.00007350288,0.00006183003,0.0001151036,0.00009089657,0.00008226235],"domain_scores_gemma":[0.9989241,0.0001815532,0.0004792786,0.00009452084,0.00004170628,0.0002788269],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002266295,0.00004239833,0.0002627615,0.00002030524,0.00001586611,0.0004494577,0.00002102275,0.0001254613,0.9979343,0.0001677889,0.00006977222,0.0006642437],"study_design_scores_gemma":[0.0001980869,0.0007856404,0.01261449,0.00003874163,0.0001186932,0.005126121,0.00007226779,0.001857153,0.9755116,0.000264512,0.003380961,0.00003180985],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923593,0.0004248025,0.004291757,0.000119913,0.00006659259,0.00004475832,0.0009599196,0.000400394,0.001332459],"genre_scores_gemma":[0.9895033,0.0005656332,0.004025299,0.00009506343,0.00004057727,0.00007589041,0.00103919,0.0002442974,0.004410686],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002932805,"threshold_uncertainty_score":0.009811223,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05214890775574387,"score_gpt":0.3718645733935748,"score_spread":0.3197156656378309,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}