{"id":"W1972771185","doi":"10.1038/nn884","title":"Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines","year":2002,"lang":"en","type":"article","venue":"Nature Neuroscience","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":1024,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Institute on Aging","keywords":"Huntingtin; Huntingtin Protein; Neurodegeneration; Mitochondrion; Biology; Huntington's disease; Calcium; Cell biology; Mutant; Genetically modified mouse; Trinucleotide repeat expansion; Transgene; Molecular biology; Genetics; Gene; Pathology; Internal medicine; Medicine; Disease; Allele","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002124583,0.0003662254,0.000467562,0.0004349861,0.0002569459,0.0003438377,0.0002826839,0.0006535617,0.001563078],"category_scores_gemma":[0.0005253828,0.0002481075,0.0002214149,0.000223249,0.0004426908,0.0005564727,0.0004016663,0.0007352743,0.0003141186],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003080836,"about_ca_system_score_gemma":0.0001239486,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008486584,"about_ca_topic_score_gemma":0.001523799,"domain_scores_codex":[0.9998891,0.00001477883,0.00002364413,0.00002343227,0.00002794429,0.00002115032],"domain_scores_gemma":[0.9994443,0.0001588293,0.0001659345,0.00005529201,0.00006782037,0.0001078321],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002644079,0.00007883771,0.007771495,0.00009971011,0.00003722432,0.005896751,0.00008771277,0.0001181505,0.9782512,0.0004174904,0.0002417581,0.004355609],"study_design_scores_gemma":[0.0003030298,0.00113104,0.2636562,0.00004052464,0.0001597851,0.02475549,0.0001612467,0.0007969105,0.7053235,0.001018343,0.002620373,0.00003360998],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959316,0.001547664,0.001070426,0.0001172825,0.00003868436,0.00001488323,0.0002875544,0.00004891221,0.0009430125],"genre_scores_gemma":[0.9979107,0.0004140218,0.0004873684,0.00003972575,0.00002546149,0.00001144764,0.0001699353,0.00001659188,0.0009247758],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001563078,"threshold_uncertainty_score":0.005228996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01598198027826318,"score_gpt":0.2652335088383072,"score_spread":0.249251528560044,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}