{"id":"W1972800518","doi":"10.1089/hgtb.2013.155","title":"AAV2/8 Vectors Purified from Culture Medium with a Simple and Rapid Protocol Transduce Murine Liver, Muscle, and Retina Efficiently","year":2013,"lang":"en","type":"article","venue":"Human Gene Therapy Methods","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Fondazione Telethon","keywords":"Lysis; Centrifugation; Biology; Ultracentrifuge; Cell culture; Differential centrifugation; Extracellular; Transduction (biophysics); Cell; Molecular biology; Cell biology; Biochemistry; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000806326,0.0003981916,0.0003562924,0.00008369893,0.0002649601,0.0001037495,0.0003157637,0.0002351674,0.0004653701],"category_scores_gemma":[0.00002511031,0.0002958744,0.00007974089,0.000160194,0.0003292027,0.00001251919,0.00009022649,0.0002519754,0.000004036954],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001549379,"about_ca_system_score_gemma":0.0000711366,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001698325,"about_ca_topic_score_gemma":0.00008331201,"domain_scores_codex":[0.9972413,0.0009075475,0.0002895679,0.0008121086,0.0002710435,0.0004784769],"domain_scores_gemma":[0.9987618,0.0000536761,0.0001143565,0.0006565163,0.0001597482,0.0002538631],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001789135,0.0001287504,0.0001671291,0.00003019631,0.0001416866,0.000005809155,0.0007836358,0.000003925998,0.9440139,0.000003156924,0.0003664078,0.05256629],"study_design_scores_gemma":[0.003870563,0.006782318,0.006319941,0.00001397144,0.00001834241,0.00001519019,0.0001125781,0.000044024,0.9604899,0.0002054731,0.02171677,0.0004109287],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9781891,0.002859203,0.001479764,0.0001056291,0.000026357,0.01711441,0.00002547883,0.00004251944,0.0001575193],"genre_scores_gemma":[0.8569189,0.003328458,0.08374125,0.001277213,0.001212047,0.05146065,0.0004810568,0.0003427596,0.001237721],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1212703,"threshold_uncertainty_score":0.9999493,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03325294322401454,"score_gpt":0.3559053005040341,"score_spread":0.3226523572800195,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}