{"id":"W1972812665","doi":"10.1016/j.bcp.2013.04.014","title":"First demonstration that brain CYP2D-mediated opiate metabolic activation alters analgesia in vivo","year":2013,"lang":"en","type":"article","venue":"Biochemical Pharmacology","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":40,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre for Addiction and Mental Health; Canada Research Chairs; University of Toronto","funders":"Canadian Institutes of Health Research; Centre for Addiction and Mental Health; National Institutes of Health; Ontario Ministry of Research and Innovation; National Institute on Drug Abuse; Ontario Ministry of Research, Innovation and Science","keywords":"Opiate; In vivo; Neuroscience; Pharmacology; Chemistry; Medicine; Anesthesia; Psychology; Biology; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002118134,0.0004501695,0.0003942866,0.0002146025,0.0002305192,0.0002920536,0.0001720519,0.0004037315,0.001547398],"category_scores_gemma":[0.0003847901,0.0002045052,0.0003428279,0.000127839,0.0003749623,0.0002094864,0.0002727718,0.001398181,0.0002633505],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003817198,"about_ca_system_score_gemma":0.0003622566,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001192499,"about_ca_topic_score_gemma":0.00239984,"domain_scores_codex":[0.9998734,0.00002875814,0.000007234773,0.00003200612,0.00003531562,0.00002328121],"domain_scores_gemma":[0.9998204,0.00004939458,0.0000235451,0.00004230389,0.00003668058,0.0000276098],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001279675,0.0001475725,0.0009226011,0.00008430361,0.00004739108,0.0001687378,0.00002228659,0.0001031793,0.9834123,0.0005977768,0.0007697524,0.01244451],"study_design_scores_gemma":[0.00009971839,0.00175193,0.0193379,0.000007488421,0.00009219797,0.001048739,0.00003654324,0.0008669242,0.9693591,0.000387025,0.006992429,0.00001988202],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9343336,0.006994435,0.04565492,0.002197203,0.0009126301,0.0002191816,0.002001555,0.0005201561,0.007166233],"genre_scores_gemma":[0.9761714,0.003291576,0.0122184,0.000538412,0.0002083184,0.0001122136,0.001031691,0.00008493798,0.00634306],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001547398,"threshold_uncertainty_score":0.005176544,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0615965428876762,"score_gpt":0.3782378347088845,"score_spread":0.3166412918212083,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}