{"id":"W1972827747","doi":"10.1152/ajpgi.00195.2014","title":"Vasoactive intestinal peptide prevents PKCε-induced intestinal epithelial barrier disruption during EPEC infection","year":2014,"lang":"en","type":"article","venue":"American Journal of Physiology-Gastrointestinal and Liver Physiology","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Child and Family Research Institute; BC Children's Hospital","funders":"Crohn's and Colitis Foundation of Canada","keywords":"Barrier function; Protein kinase C; Enteropathogenic Escherichia coli; Vasoactive intestinal peptide; Tight junction; Citrobacter rodentium; Cell biology; Intestinal mucosa; Chemistry; Biology; Signal transduction; Inflammation; Immunology; Medicine; Internal medicine; Escherichia coli; Receptor; Biochemistry; Neuropeptide","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002685311,0.0004599054,0.0008451797,0.0002777057,0.0004375849,0.00003159852,0.0002830101,0.00005681455,0.00006668204],"category_scores_gemma":[0.00111243,0.0003633525,0.0002537691,0.0003521684,0.001315553,0.0004044296,0.0002418624,0.0009161425,0.00002245911],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008141902,"about_ca_system_score_gemma":0.00007719508,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001450328,"about_ca_topic_score_gemma":0.000008461632,"domain_scores_codex":[0.9969574,0.0008354646,0.0006876221,0.0006659113,0.000259164,0.000594449],"domain_scores_gemma":[0.9971544,0.0008063772,0.001209204,0.0002410167,0.0003038148,0.0002852296],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001060767,0.0001150178,0.005285184,0.00003530211,0.00005288279,0.0000169427,0.0003295277,0.00007561027,0.9857075,0.0003603648,0.00002826817,0.006932623],"study_design_scores_gemma":[0.001452322,0.009302513,0.8682485,0.0002638811,0.0001743407,0.00892006,0.0003573716,0.0004216689,0.1057996,0.004425865,0.0001613084,0.0004726097],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972202,0.00001646592,0.001820598,0.00008981042,0.000461383,0.0001404427,0.000009395462,0.00005558802,0.0001861378],"genre_scores_gemma":[0.9967706,0.0000510704,0.001618038,0.0003278145,0.001137462,0.00001241322,0.00000276624,0.00003146149,0.00004833002],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.879908,"threshold_uncertainty_score":0.9998819,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01305211029563139,"score_gpt":0.2432402946827324,"score_spread":0.230188184387101,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}